Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, 31270-901, MG, Brazil.
Chem Commun (Camb). 2018 Jul 3;54(54):7398-7411. doi: 10.1039/c8cc03147a.
Compounds featuring weakly-coordinating N-oxides or carbonyl groups, as for instance, quinoline N-oxide and quinonoid systems represent important structural scaffolds with potential biological activities. Due to their biological importance, significant efforts have been devoted to devise robust methods for their step-economical preparation. Among these approaches, the C-H activation strategy has emerged as a powerful, versatile and efficient tool in molecular sciences. This feature article summarizes recent key advances in transition-metal-catalyzed C-H functionalization for A-ring functionalization of heterocyclic and quinoidal compounds by challenging weakly-coordinating entities, published prior to May 2018.
具有弱配位 N-氧化物或羰基的化合物，例如喹啉 N-氧化物和醌式体系，代表了具有潜在生物活性的重要结构支架。由于其生物学重要性，人们已经投入了大量的精力来设计用于其经济高效制备的稳健方法。在这些方法中，C-H 活化策略已成为分子科学中一种强大、通用和有效的工具。本文综述了 2018 年 5 月之前发表的关于通过挑战性弱配位实体实现杂环和醌式化合物 A 环官能化的过渡金属催化 C-H 官能化的最新关键进展。
