羧酸盐配体对钯催化的分子内C(sp³)-H和C(sp²)-H芳基化反应的空间效应
Steric Effect of Carboxylate Ligands on Pd-Catalyzed Intramolecular C(sp )-H and C(sp )-H Arylation Reactions.
作者信息
Tanji Yutaka, Mitsutake Naoya, Fujihara Tetsuaki, Tsuji Yasushi
机构信息
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, 615-8510, Japan.
出版信息
Angew Chem Int Ed Engl. 2018 Aug 6;57(32):10314-10317. doi: 10.1002/anie.201804566. Epub 2018 Jun 19.
A bulky carboxylic acid bearing three cyclohexylmethyl substituents at the α-position, namely, tri(cyclohexylmethyl)acetic acid, is demonstrated to act as an efficient ligand source in Pd-catalyzed intramolecular C(sp )-H and C(sp )-H arylation reactions. The reactions proceed smoothly under mild reaction conditions, even at room temperature due to the steric bulk of the carboxylate ligands, which accelerates the rate-determining C-H bond activation step in the catalytic cycle.
一种在α位带有三个环己基甲基取代基的庞大羧酸，即三（环己基甲基）乙酸，被证明在钯催化的分子内C(sp³)-H和C(sp²)-H芳基化反应中作为一种有效的配体来源。由于羧酸根配体的空间位阻，反应在温和的反应条件下，甚至在室温下也能顺利进行，这加速了催化循环中决定反应速率的C-H键活化步骤。
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