钯催化的分子间碳氢键芳基化反应：羧酸盐配体空间位阻的影响
Pd-Catalyzed intermolecular C-H bond arylation reactions: effect of bulkiness of carboxylate ligands.
作者信息
Tanji Yutaka, Hamaguchi Ryo, Tsuji Yasushi, Fujihara Tetsuaki
机构信息
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
出版信息
Chem Commun (Camb). 2020 Apr 7;56(27):3843-3846. doi: 10.1039/d0cc01129k. Epub 2020 Mar 11.
PMID:32159546
Abstract
A bulky carboxylic acid bearing one 1-adamantylmethyl and two methyl substituents at the α-position is demonstrated to work as an efficient carboxylate ligand source in Pd-catalyzed intermolecular C(sp)-H bond arylation reactions. The reactions proceeded smoothly under mild conditions, taking advantage of the steric bulk of the carboxylate ligands.
摘要
一种在α位带有一个1-金刚烷基甲基和两个甲基取代基的庞大羧酸被证明在钯催化的分子间C(sp)-H键芳基化反应中可作为一种有效的羧酸盐配体源。利用羧酸盐配体的空间位阻，反应在温和条件下顺利进行。
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