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肾脏监测成为焦点：对比剂相关急性肾损伤得到阐明。

Kidney surveillance in the spotlight: contrast-induced acute kidney injury illuminated.

出版信息

J Clin Invest. 2018 Jul 2;128(7):2754-2756. doi: 10.1172/JCI121741. Epub 2018 Jun 4.

DOI:10.1172/JCI121741
PMID:29863496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6025966/
Abstract

Acute kidney injury comprises a heterogeneous group of conditions characterized by a sudden decrease in renal function over hours to days. Contrast-induced acute kidney injury (CI-AKI) is caused by radiographic contrast agents used in diagnostic imaging. In the current issue of the JCI, Lau et al. use a mouse model of CI-AKI to study the role of resident and infiltrating phagocytes, recruited leukocytes, and tubular cells in the immune surveillance response to contrast agents. This study has the potential to provide innovative therapies for human CI-AKI.

摘要

急性肾损伤包括一组异质性疾病，其特征是肾功能在数小时至数天内突然下降。对比剂诱导的急性肾损伤（CI-AKI）是由诊断成像中使用的造影剂引起的。在本期 JCI 中，Lau 等人使用 CI-AKI 的小鼠模型研究了固有和浸润性吞噬细胞、募集的白细胞和肾小管细胞在对比剂免疫监视反应中的作用。这项研究有可能为人类 CI-AKI 提供创新的治疗方法。

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本文引用的文献

1
Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.肾免疫监视和二肽酶-1 有助于对比剂诱导的急性肾损伤。
J Clin Invest. 2018 Jul 2;128(7):2894-2913. doi: 10.1172/JCI96640. Epub 2018 Jun 4.
2
Inflammasome Complexes: Emerging Mechanisms and Effector Functions.炎性小体复合物：新出现的机制与效应功能
Cell. 2016 May 5;165(4):792-800. doi: 10.1016/j.cell.2016.03.046.
3
Cellular and Molecular Mechanisms of AKI.急性肾损伤的细胞和分子机制
J Am Soc Nephrol. 2016 May;27(5):1288-99. doi: 10.1681/ASN.2015070740. Epub 2016 Feb 9.
4
Acute Kidney Injury.急性肾损伤
Annu Rev Med. 2016;67:293-307. doi: 10.1146/annurev-med-050214-013407.
5
Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps.急性肾损伤中的炎症：当前认识、关键问题及知识空白
J Am Soc Nephrol. 2016 Feb;27(2):371-9. doi: 10.1681/ASN.2015030261. Epub 2015 Nov 11.
6
Contrast-Induced Nephropathy: From Pathophysiology to Preventive Strategies.造影剂诱导的肾病：从病理生理学到预防策略
Can J Cardiol. 2016 Feb;32(2):247-55. doi: 10.1016/j.cjca.2015.05.013. Epub 2015 May 23.
7
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD.NLRP3 炎性小体促进肾脏炎症，并有助于 CKD 的发生。
J Am Soc Nephrol. 2010 Oct;21(10):1732-44. doi: 10.1681/ASN.2010020143. Epub 2010 Aug 5.
8
Functional studies of the kidney of living animals using multicolor two-photon microscopy.使用多色双光子显微镜对活体动物肾脏进行功能研究。
Am J Physiol Cell Physiol. 2002 Sep;283(3):C905-16. doi: 10.1152/ajpcell.00159.2002.
9
Effects of saline, mannitol, and furosemide on acute decreases in renal function induced by radiocontrast agents.生理盐水、甘露醇和呋塞米对造影剂所致肾功能急性减退的影响。
N Engl J Med. 1994 Nov 24;331(21):1416-20. doi: 10.1056/NEJM199411243312104.