Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2819-511 Caparica, Portugal.
Centro Hospitalar de Lisboa Central, EPE, Hospital de Santo António dos Capuchos, Departamento de Neurociências, Alameda de Santo António dos Capuchos, 1169-050 Lisboa, Portugal.
Int J Mol Sci. 2018 Jun 1;19(6):1639. doi: 10.3390/ijms19061639.
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Then, the involvement of biochemical pathways is discussed in the development and repair of the CNS lesions and the immune dysfunction in the disease. Finally, the potential roles of peroxisome proliferator-activated receptors (PPAR) in MS are discussed. It is suggested that metabolic mechanisms modulated by PPAR provide a window to integrate the systemic and neurological events underlying the pathogenesis of the disease. In conclusion, the reviewed data highlight molecular avenues of understanding MS that may open new targets for improved therapies and preventive strategies for the disease.
多发性硬化症（MS）是一种中枢神经系统（CNS）的炎症性和神经退行性疾病，可能由遗传和环境因素相互作用引起。本文首先总结了 MS 的一些临床、流行病学和病理学特征。然后，讨论了生化途径在 CNS 损伤的发展和修复以及疾病中的免疫功能障碍中的作用。最后，讨论了过氧化物酶体增殖物激活受体（PPAR）在 MS 中的潜在作用。研究表明，PPAR 调节的代谢机制为整合疾病发病机制中涉及的全身和神经事件提供了一个窗口。总之，综述的数据突出了理解 MS 的分子途径，这些途径可能为该疾病的治疗和预防策略提供新的靶点。
