Dinsmore Charles E, Hanken James
Department of Anatomy, Rush Medical College, Chicago, Illinois 60612.
Department of Environmental, Population and Organismic Biology, University of Colorado, Boulder, Colorado 80309-0334.
J Morphol. 1990 Jul;205(1):77-84. doi: 10.1002/jmor.1052050108.
Comparison of mesopodial skeletal patterns found in native and regenerated limbs of the salamander Plethodon cinereus reveals variant patterns unique to each group. Variant patterns in native limbs are based on fusions between laterally adjacent elements (i.e., in the anteroposterior axis). Variant patterns in the mesopodia of regenerated limbs usually exhibit fusions among proximodistally adjacent elements. Analysis of regenerates derived from limb amputation at different levels shows that the axis of fusion between regenerated mesopodial elements remains the same (i.e., proximodistal) independent of amputation level. However, the frequency of specific fusion combinations is unexpectedly sensitive to amputation level. Proximal (stylopodial) amputation results in mesopodial patterns with predominantly preaxial fusion combinations; distal amputation produces mesopodial patterns with predominantly postaxial fusion combinations. This finding is discussed in the context of other recent studies in which amputation level influenced limb regeneration patterning.
对灰林螈（Plethodon cinereus）原生肢体和再生肢体中中足骨骼模式的比较揭示了每组独特的变异模式。原生肢体中的变异模式基于横向相邻元素之间的融合（即前后轴方向）。再生肢体中足的变异模式通常表现为近端-远端相邻元素之间的融合。对不同水平肢体截肢后再生体的分析表明，再生中足元素之间的融合轴保持不变（即近端-远端），与截肢水平无关。然而，特定融合组合的频率对截肢水平出人意料地敏感。近端（肩带部）截肢导致中足模式主要为轴前融合组合；远端截肢产生的中足模式主要为轴后融合组合。这一发现将在其他近期研究的背景下进行讨论，这些研究中截肢水平影响了肢体再生模式。
