免疫衰老对中性粒细胞和淋巴细胞表面分子低表达的影响。

Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes.

作者信息

Lopes Alessandra B, Lopes Larissa B, da Silveira Antunes Roseli N, Fukasawa Josianne T, de A Cavaretto Débora, Calamita Zamir

机构信息

Postgraduate Program in Health and Aging, Marilia School of Medicine - FAMEMA, Rua Monte Carmelo, 800, Fragata, CEP: 17519-030, Marilia - SP, Brazil.

Discipline of Hematology and Hemotherapy of the Federal University of Sao Paulo - UNIFESP, Rua Doutor Diogo de Faria, 824, Vila Clementino, CEP: 04037-002, Sao Paulo - SP, Brazil.

出版信息

Curr Aging Sci. 2018;11(2):118-125. doi: 10.2174/1874609811666180605092234.

DOI:10.2174/1874609811666180605092234

PMID:29866027

Abstract

BACKGROUND

Immunosenescence is a remodeling of the immune system, caused by aging, with changes in the function of neutrophils, lymphocytes, and Treg cells.

OBJECTIVE

This study aimed to evaluate the expression of molecules CD11b, CD16 and CD64 (neutrophils), CD154 (T lymphocytes), CD40 (B lymphocytes), and to quantitatively analyze the Treg cell subpopulation.

METHODS

49 elderlies (≥60 years) and 49 adults (≤35 years) were studied. Flow cytometry was used to analyze the expression of surface molecules and the subpopulation of Treg cells, and the results between the groups were compared statistically by the t-test.

RESULTS

There was a decreased significance in the expression of CD11b and CD40 in the elderly.

CONCLUSION

Decreased CD11b expression can result in susceptibility to infectious diseases, and impairment of phagocytic capacity. Decreased CD40 expression can result in a decline in B lymphocyte activation. The other molecule studied presented alterations not significant, but compatible with the immunological changes in aging.

摘要