Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
Front Immunol. 2021 May 12;12:681449. doi: 10.3389/fimmu.2021.681449. eCollection 2021.
Immunosenescence is a process associated with aging that leads to dysregulation of cells of innate and adaptive immunity, which may become dysfunctional. Consequently, older adults show increased severity of viral and bacterial infections and impaired responses to vaccinations. A better understanding of the process of immunosenescence will aid the development of novel strategies to boost the immune system in older adults. In this review, we focus on major alterations of the immune system triggered by aging, and address the effect of chronic viral infections, effectiveness of vaccination of older adults and strategies to improve immune function in this vulnerable age group.
免疫衰老（Immunosenescence）是与衰老相关的一个过程，它会导致固有免疫和适应性免疫细胞的失调，并可能导致其功能障碍。因此，老年人的病毒和细菌感染严重程度增加，对疫苗的反应受损。更好地了解免疫衰老过程将有助于开发新的策略来增强老年人的免疫系统。在这篇综述中，我们重点关注衰老引发的免疫系统的主要变化，并探讨慢性病毒感染的影响、老年人疫苗接种的有效性以及改善这一年龄脆弱群体免疫功能的策略。
