School of Pharmacy and Medical Sciences, University of South Australia, Frome Road, Adelaide 5000, South Australia, Australia.
Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Frome Road, Adelaide 5000, South Australia, Australia.
Int J Environ Res Public Health. 2018 Jun 4;15(6):1166. doi: 10.3390/ijerph15061166.
Intermittent energy restriction is a popular alternative to daily energy restriction for weight loss; however, it is unknown if endothelial function, a risk factor for cardiovascular disease, is altered by periods of severe energy restriction. The objective of the study was to determine the impact of two consecutive very low energy intake days, which is the core component of the 5:2 intermittent energy restriction diet strategy, on endothelial function compared to consecutive ad libitum eating days. The secondary objective was to explore the effects of these dietary conditions on fasting glucose concentrations. This was a 4-week randomized, single-blinded, crossover study of 35 participants. Participants consumed a very low energy diet (500 calories for women, 600 calories for men) on two consecutive days per week and 5 days of habitual eating. In weeks 3 and 4 of the trial, participants had measurements of flow mediated dilatation (FMD) and blood samples taken following either 2 habitual eating days or 2 energy restricted days in a randomized order. FMD values were not different after the two eating states (8.6% vs. 8.3%, = 0.7). All other outcome variables were unchanged. Endothelial function, as measured by flow mediated dilatation, was not altered by two consecutive very low energy intake days. Further investigations assessing the impact in specific population groups as well as different testing conditions would be beneficial.
间歇性能量限制是一种替代每日能量限制的减肥方法；然而，目前尚不清楚内皮功能（心血管疾病的一个风险因素）是否会因严重的能量限制期而改变。本研究的目的是确定与连续的随意进食日相比，连续两天极低能量摄入（这是 5:2 间歇性能量限制饮食策略的核心组成部分）对内皮功能的影响。次要目的是探讨这些饮食条件对空腹血糖浓度的影响。这是一项为期 4 周的随机、单盲、交叉研究，共有 35 名参与者。参与者每周连续两天摄入极低能量饮食（女性 500 卡路里，男性 600 卡路里），并连续 5 天进行习惯性进食。在试验的第 3 和第 4 周，参与者按照随机顺序分别在 2 个习惯性进食日或 2 个能量限制日之后进行血流介导的扩张（FMD）测量和血液样本采集。两种进食状态后 FMD 值无差异（8.6% vs. 8.3%， = 0.7）。所有其他观察结果均未改变。通过血流介导的扩张测量的内皮功能并未因连续两天极低能量摄入而改变。进一步评估特定人群组和不同测试条件影响的研究将是有益的。
