维生素 D₃ 状态与不同临床类型活动性结核病患者人防御素表达的关系。
Vitamin D₃ Status and the Association with Human Cathelicidin Expression in Patients with Different Clinical Forms of Active Tuberculosis.
机构信息
Center for Infectious Medicine (CIM), F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.
Department of Surgery, Faculty of Medicine, Black Lion University Hospital and Addis Ababa University, P.O Box: 28287/1000, Addis Ababa, Ethiopia.
出版信息
Nutrients. 2018 Jun 4;10(6):721. doi: 10.3390/nu10060721.
Low vitamin D (vitD₃) is one of the most common nutritional deficiencies in the world known to be associated with numerous medical conditions including infections such as tuberculosis (TB). In this study, vitD₃ status and its association with the antimicrobial peptide, human cathelicidin (LL-37), was investigated in Ethiopian patients with different clinical forms of TB. Patients with active TB ( = 77) and non-TB controls ( = 78) were enrolled in Ethiopia, while another group of non-TB controls ( = 62) was from Sweden. Active TB included pulmonary TB ( 32), pleural TB ( = 20), and lymph node TB ( = 25). Concentrations of 25-hydroxyvitamin D₃ (25(OH)D₃) were assessed in plasma, while LL-37 mRNA was measured in peripheral blood and in samples obtained from the site of infection. Median 25(OH)D₃ plasma levels in active TB patients were similar to Ethiopian non-TB controls (38.5 versus 35.0 nmol/L) and vitD₃ deficiency (.
维生素 D 水平低（vitD₃）是世界上最常见的营养缺乏症之一，已知与许多医学病症有关，包括结核病（TB）等感染。在这项研究中，研究了埃塞俄比亚不同临床类型的结核病患者的 vitD₃ 状况及其与抗菌肽人防御素（LL-37）的关系。在埃塞俄比亚招募了活动性结核病（TB）患者（=77）和非 TB 对照组（=78），而另一组非 TB 对照组（=62）来自瑞典。活动性 TB 包括肺结核（=32）、胸膜炎 TB（=20）和淋巴结 TB（=25）。在血浆中评估 25-羟维生素 D₃（25（OH）D₃）浓度，同时在外周血和感染部位获得的样本中测量 LL-37 mRNA。活动性 TB 患者的中位 25（OH）D₃ 血浆水平与埃塞俄比亚非 TB 对照组相似（38.5 与 35.0 nmol/L），vitD₃ 缺乏症（。
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