Bi Xia-An, Zhao Junxia, Xu Qian, Sun Qi, Wang Zhigang
College of Mathematics and Computer Science, Hunan Normal University, Changsha, China.
Front Physiol. 2018 May 8;9:475. doi: 10.3389/fphys.2018.00475. eCollection 2018.
Some functional magnetic resonance imaging (fMRI) researches in autism spectrum disorder (ASD) patients have shown that ASD patients have significant impairment in brain response. However, few researchers have studied the functional structure changes of the eight resting state networks (RSNs) in ASD patients. Therefore, research on statistical differences of RSNs between 42 healthy controls (HC) and 50 ASD patients has been studied using linear independent component analysis (ICA) in this paper. Our researches showed that there was abnormal functional connectivity (FC) of RSNs in ASD patients. The RSNs with the decreased FC and increased FC in ASD patients included default mode network (DMN), central executive network (CEN), core network (CN), visual network (VN), self-referential network (SRN) compared to HC. The RSNs with the increased FC in ASD patients included auditory network (AN), somato-motor network (SMN). The dorsal attention network (DAN) in ASD patients showed the decreased FC. Our findings indicate that the abnormal FC in RSNs extensively exists in ASD patients. Our results have important contribution for the study of neuro-pathophysiological mechanisms in ASD patients.
一些针对自闭症谱系障碍（ASD）患者的功能磁共振成像（fMRI）研究表明，ASD患者的大脑反应存在显著损伤。然而，很少有研究人员对ASD患者八个静息态网络（RSN）的功能结构变化进行研究。因此，本文采用线性独立成分分析（ICA）研究了42名健康对照者（HC）和50名ASD患者之间RSN的统计差异。我们的研究表明，ASD患者的RSN存在异常功能连接（FC）。与HC相比，ASD患者中FC降低和FC增加的RSN包括默认模式网络（DMN）、中央执行网络（CEN）、核心网络（CN）、视觉网络（VN）、自我参照网络（SRN）。ASD患者中FC增加的RSN包括听觉网络（AN）、躯体运动网络（SMN）。ASD患者的背侧注意网络（DAN）显示FC降低。我们的研究结果表明，RSN中的异常FC在ASD患者中广泛存在。我们的结果对ASD患者神经病理生理机制的研究具有重要贡献。
