Livezey G T, Radulovacki M, Isaac L, Marczynski T J
Brain Res. 1985 May 20;334(2):361-5. doi: 10.1016/0006-8993(85)90233-1.
After prenatal exposure to diazepam (Valium), mature rats at 4 months of age displayed slow wave sleep (SWS) electroencephalographic patterns indicating impaired synchronization and SWS mechanisms. These animals spent a much greater portion of their SWS in the lighter SWS I, as compared to the control group which showed a predominance of the deeper SWS II. At one year of age, the diazepam-exposed rats had much fewer diazepam-specific binding sites in the thalamus than the vehicle-exposed controls. These results provide first evidence for a physiological role for benzodiazepine receptors by showing that prenatal exposure to diazepam has an enduring and detrimental effect on their ontogenesis and sleep mechanisms.
在产前暴露于地西泮（安定）后，4个月大的成年大鼠表现出慢波睡眠（SWS）脑电图模式，表明同步化和SWS机制受损。与显示更深的SWS II占主导的对照组相比，这些动物在较轻的SWS I中花费了更多比例的SWS时间。在1岁时，暴露于地西泮的大鼠丘脑的地西泮特异性结合位点比暴露于赋形剂的对照组少得多。这些结果通过表明产前暴露于地西泮对其个体发育和睡眠机制具有持久且有害的影响，首次为苯二氮䓬受体的生理作用提供了证据。
