Livezey G T, Marczynski T J, Isaac L
Neurotoxicology. 1986 Summer;7(2):319-33.
Pregnant cats were treated with a benzodiazepine receptor agonist, diazepam (DZ; Valium; average dose of 0.4 mg/kg/day, i.m.) between day 20 through day 53 of gestation in an attempt to alter the ontogenesis of the benzodiazepine receptors. As tested in fully developed one-year-old progenies, prenatal exposure to DZ resulted in a behavioral syndrome of hyperactivity, aggressiveness, behavioral signs of chronic anxiety, inability to habituate to novel environment, suppression or absence of the reward-induced alpha-like (7 to 11 Hz) electroencephalographic patterns during operantly conditioned behavior (bar pressing for 1 ml of milk reward), and deficits in the numbers of benzodiazepine receptors in the hypothalamus (-47%), fronto-orbital cortex (-33%) and postcentral cortex (-19%).
在妊娠第20天至第53天期间，给怀孕的猫注射一种苯二氮䓬受体激动剂——地西泮（DZ；安定；平均剂量为0.4毫克/千克/天，肌肉注射），试图改变苯二氮䓬受体的个体发生。在完全发育的一岁后代中进行测试时，产前接触地西泮会导致一种行为综合征，包括多动、攻击性、慢性焦虑的行为迹象、无法适应新环境、在操作性条件行为（按压杠杆以获得1毫升牛奶奖励）期间抑制或缺乏奖励诱导的α样（7至11赫兹）脑电图模式，以及下丘脑（-47%）、额眶皮质（-33%）和中央后皮质（-19%）中苯二氮䓬受体数量的减少。
