Livezey G T, Marczynski T J, Isaac L
Neurobehav Toxicol Teratol. 1986 Sep-Oct;8(5):425-32.
Pregnant rats were treated with daily doses (5.0 to 7.5 mg/kg, SC) of the benzodiazepine (BDZ) receptor agonist, diazepam (DZ) between day 15 through day 20 of gestation, i.e., during ontogenesis of BDZ receptors in an attempt to alter their development. In the radial arm maze, 6 months old rat progeny showed behavioral anomalies and deficient exploratory behavior. One plausible interpretation of their poor performance is a deficit in short-term spatial "working memory." However, a more detailed evaluation of their behavior suggests a chronic state of hyperarousal/anxiety and thus, poor focus of attention on the task at hand. In addition, the number of brain BDZ receptors in the thalamus, at the age of one year, was significantly reduced. Hence, prenatal exposure to DZ has enduring and detrimental effects on brain function.
在妊娠第15天至第20天期间，给怀孕大鼠每日皮下注射剂量为5.0至7.5毫克/千克的苯二氮䓬（BDZ）受体激动剂地西泮（DZ），即在BDZ受体的个体发生期间，试图改变其发育。在放射状臂迷宫实验中，6个月大的大鼠后代表现出行为异常和探索行为缺陷。对它们表现不佳的一种合理的解释是短期空间“工作记忆”存在缺陷。然而，对它们行为的更详细评估表明，它们处于一种慢性的过度兴奋/焦虑状态，因此对手头任务的注意力难以集中。此外，一岁时丘脑的脑BDZ受体数量显著减少。因此，产前接触DZ对脑功能有持久的有害影响。
