• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

经典树突状细胞中的干扰素基因刺激因子控制黏膜Th17对环二核苷酸的反应，以抵御肠道微生物感染，保护宿主。

Stimulator of Interferon Genes in Classical Dendritic Cells Controls Mucosal Th17 Responses to Cyclic Dinucleotides for Host Defenses Against Microbial Infections in Gut.

作者信息

Liu Song, Xia Qiuyuan, Wu Xiuwen, Sun Feng, Hu Qiongyuan, Wu Jie, Wang Meng, Rao Qiu, Guan Wenxian

机构信息

Department of General Surgery, Nanjing Drum Tower Hospital, Nanjing, China.

School of Medicine, Nanjing University, Nanjing, China.

出版信息

Front Immunol. 2018 May 16;9:1085. doi: 10.3389/fimmu.2018.01085. eCollection 2018.

DOI:10.3389/fimmu.2018.01085
PMID:29868030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5964311/
Abstract

Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, stimulator of interferon genes (STING) encoded by . In this study, we demonstrate that STING triggers adaptive immune responses that control Th17 differentiation. Cyclic dinucleotides recognition enables classical dendritic cells (cDCs) that predominantly express CD103 to induce Th17 lymphocytes in an IL-6/IL-1β-dependent manner in gut. STING expression in human lamina propria is associated with the severity of mucosal inflammation and clinical disease activity in patients with Crohn's disease. Mice deficient in fail to mount Th17 responses to cyclic dinucleotides or prevent immune evasion of enteroinvasive pathogens. In summary, STING in mucosal cDCs controls Th17 subspecification that is essential for host defenses against microbial infection in gut-associated immune system.

摘要

环二核苷酸是细菌信号转导分子，可与宿主细胞内由……编码的蛋白质——干扰素基因刺激因子（STING）结合。在本研究中，我们证明STING触发适应性免疫反应，控制Th17细胞分化。环二核苷酸识别使主要表达CD103的经典树突状细胞（cDCs）能够以IL-6/IL-1β依赖的方式在肠道中诱导Th17淋巴细胞。人类固有层中STING的表达与克罗恩病患者黏膜炎症的严重程度和临床疾病活动相关。缺乏……的小鼠无法对环二核苷酸产生Th17反应，也无法防止肠道侵袭性病原体的免疫逃逸。总之，黏膜cDCs中的STING控制Th17亚群分化，这对于肠道相关免疫系统中宿主抵御微生物感染至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/0ce7e629658d/fimmu-09-01085-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/8e86d9c634a2/fimmu-09-01085-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/af2749b8a772/fimmu-09-01085-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/71ef131924a9/fimmu-09-01085-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/49ecc62a982e/fimmu-09-01085-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/0ce7e629658d/fimmu-09-01085-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/8e86d9c634a2/fimmu-09-01085-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/af2749b8a772/fimmu-09-01085-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/71ef131924a9/fimmu-09-01085-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/49ecc62a982e/fimmu-09-01085-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f9/5964311/0ce7e629658d/fimmu-09-01085-g005.jpg

相似文献

1
Stimulator of Interferon Genes in Classical Dendritic Cells Controls Mucosal Th17 Responses to Cyclic Dinucleotides for Host Defenses Against Microbial Infections in Gut.经典树突状细胞中的干扰素基因刺激因子控制黏膜Th17对环二核苷酸的反应，以抵御肠道微生物感染，保护宿主。
Front Immunol. 2018 May 16;9:1085. doi: 10.3389/fimmu.2018.01085. eCollection 2018.
2
Retraction: Stimulator of Interferon Genes in Classical Dendritic Cells Controls Mucosal Th17 Responses to Cyclic Dinucleotides for Host Defenses Against Microbial Infections in Gut.撤回声明：经典树突状细胞中的干扰素基因刺激物控制黏膜Th17对环状二核苷酸的反应，以抵御肠道微生物感染实现宿主防御。
Front Immunol. 2019 Jun 14;10:1468. doi: 10.3389/fimmu.2019.01468. eCollection 2019.
3
T cell fate following infection is determined by a STING-IRF1 signaling axis in mice.在小鼠中，感染后 T 细胞的命运由 STING-IRF1 信号轴决定。
Commun Biol. 2019 Dec 11;2:464. doi: 10.1038/s42003-019-0701-2. eCollection 2019.
4
Cytosolic sensor STING in mucosal immunity: a master regulator of gut inflammation and carcinogenesis.细胞质传感器 STING 在黏膜免疫中的作用：肠道炎症和癌变的主要调节因子。
J Exp Clin Cancer Res. 2021 Jan 23;40(1):39. doi: 10.1186/s13046-021-01850-9.
5
Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's disease.克罗恩病患者肠道固有层中 CD14+CD163low 髓系细胞诱导 Th17 活性增强。
Gastroenterology. 2013 Dec;145(6):1380-91.e1. doi: 10.1053/j.gastro.2013.08.049. Epub 2013 Aug 29.
6
Gut Epithelial Vitamin D Receptor Regulates Microbiota-Dependent Mucosal Inflammation by Suppressing Intestinal Epithelial Cell Apoptosis.肠道上皮维生素D受体通过抑制肠上皮细胞凋亡来调节微生物群依赖性黏膜炎症。
Endocrinology. 2018 Feb 1;159(2):967-979. doi: 10.1210/en.2017-00748.
7
Role of the IL-23/IL-17 axis in Crohn's disease.白细胞介素-23/白细胞介素-17轴在克罗恩病中的作用。
Discov Med. 2012 Oct;14(77):253-62.
8
Th17 cells, HIV and the gut mucosal barrier.辅助性 T 细胞 17、HIV 和肠道黏膜屏障。
Curr Opin HIV AIDS. 2010 Mar;5(2):173-8. doi: 10.1097/COH.0b013e328335eda3.
9
Mechanisms and pathways of innate immune activation and regulation in health and cancer.健康与癌症中固有免疫激活和调节的机制与途径。
Hum Vaccin Immunother. 2014;10(11):3270-85. doi: 10.4161/21645515.2014.979640.
10
Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi.用Tc52或其氨基末端结构域与c-di-AMP佐剂一起免疫可诱导Th17+Th1特异性免疫反应，并赋予对克氏锥虫的保护作用。
PLoS Negl Trop Dis. 2017 Feb 24;11(2):e0005300. doi: 10.1371/journal.pntd.0005300. eCollection 2017 Feb.

引用本文的文献

1
STING-mediated intestinal barrier dysfunction contributes to lethal sepsis.STING 介导的肠道屏障功能障碍导致致命性脓毒症。
EBioMedicine. 2019 Mar;41:497-508. doi: 10.1016/j.ebiom.2019.02.055. Epub 2019 Mar 14.
2
STING Signaling Promotes Apoptosis, Necrosis, and Cell Death: An Overview and Update.STING 信号促进细胞凋亡、坏死和细胞死亡：概述与更新。
Mediators Inflamm. 2018 Nov 25;2018:1202797. doi: 10.1155/2018/1202797. eCollection 2018.

本文引用的文献

1
Signalling strength determines proapoptotic functions of STING.信号强度决定了STING的促凋亡功能。
Nat Commun. 2017 Sep 5;8(1):427. doi: 10.1038/s41467-017-00573-w.
2
Human genetic variation and the gut microbiome in disease.人类遗传变异与疾病中的肠道微生物组。
Nat Rev Genet. 2017 Nov;18(11):690-699. doi: 10.1038/nrg.2017.63. Epub 2017 Aug 21.
3
Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death.前沿：T细胞中STING的激活诱导I型干扰素反应和细胞死亡。
J Immunol. 2017 Jul 15;199(2):397-402. doi: 10.4049/jimmunol.1601999. Epub 2017 Jun 14.
4
Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes.天然免疫传感器STING在T淋巴细胞中的内在抗增殖活性。
J Exp Med. 2017 Jun 5;214(6):1769-1785. doi: 10.1084/jem.20161674. Epub 2017 May 8.
5
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.疫苗佐剂壳聚糖通过DNA传感器cGAS-STING依赖性诱导I型干扰素促进细胞免疫。
Immunity. 2016 Mar 15;44(3):597-608. doi: 10.1016/j.immuni.2016.02.004. Epub 2016 Mar 2.
6
Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond.STING信号通路对线粒体DNA的感知参与炎症、癌症及其他相关过程。
Int J Cancer. 2016 Aug 15;139(4):736-41. doi: 10.1002/ijc.30074. Epub 2016 Mar 25.
7
CD103(+) Dendritic Cells Control Th17 Cell Function in the Lung.CD103(+)树突状细胞调控肺部Th17细胞功能。
Cell Rep. 2015 Sep 22;12(11):1789-801. doi: 10.1016/j.celrep.2015.08.030. Epub 2015 Sep 10.
8
Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses.肠道单核细胞衍生的巨噬细胞控制共生菌特异性Th17反应。
Cell Rep. 2015 Aug 25;12(8):1314-24. doi: 10.1016/j.celrep.2015.07.040. Epub 2015 Aug 13.
9
Microbial DNA recognition by cGAS-STING and other sensors in dendritic cells in inflammatory bowel diseases.炎症性肠病中树突状细胞内cGAS-STING及其他传感器对微生物DNA的识别
Inflamm Bowel Dis. 2015 Apr;21(4):901-11. doi: 10.1097/MIB.0000000000000299.
10
Cyclic GMP-AMP displays mucosal adjuvant activity in mice.环鸟苷酸-腺苷酸在小鼠中表现出黏膜佐剂活性。
PLoS One. 2014 Oct 8;9(10):e110150. doi: 10.1371/journal.pone.0110150. eCollection 2014.