Hough Rebecca F, Bhattacharya Sunita, Bhattacharya Jahar
1 Lung Biology Lab, Columbia University College of Physicians & Surgeons, New York, NY, USA.
2 Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, NY, USA.
Pulm Circ. 2018 Jul-Sep;8(3):2045894018783735. doi: 10.1177/2045894018783735. Epub 2018 Jun 5.
Crosstalk signaling between the closely juxtaposed epithelial and endothelial membranes of pulmonary alveoli establishes the lung's immune defense against inhaled and blood-borne pathogens. The crosstalk can occur in a forward direction, as from alveolus to capillary, or in a reverse direction, as from capillary to alveolus. The crosstalk direction likely depends on the site at which pathogens first initiate signaling. Thus, forward crosstalk may occur when inhaled pathogens encounter the alveolar epithelium, while reverse crosstalk may result from interactions of blood-borne pathogens with the endothelium. Here, we review the factors that regulate these two directions of signaling.
肺泡紧密相邻的上皮膜和内皮膜之间的串扰信号建立了肺部针对吸入性和血源性病原体的免疫防御。串扰可以正向发生，即从肺泡到毛细血管，也可以反向发生，即从毛细血管到肺泡。串扰方向可能取决于病原体首先启动信号的部位。因此，当吸入性病原体遇到肺泡上皮时可能发生正向串扰，而血源性病原体与内皮的相互作用可能导致反向串扰。在这里，我们综述了调节这两种信号传导方向的因素。
