微小 RNA 在脑卒中的作用：可能的治疗靶点。
The Roles of MicroRNAs in Stroke: Possible Therapeutic Targets.
机构信息
1 Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
4 Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
出版信息
Cell Transplant. 2018 Dec;27(12):1778-1788. doi: 10.1177/0963689718773361. Epub 2018 Jun 5.
Stroke is one of the most devastating diseases worldwide. In recent years, a great number of studies have focused on the effects of microRNAs (miRNAs) on stroke and the results demonstrated that the expressions of miRNAs are associated with the prognosis of stroke. In the present study, we review relevant articles regarding miRNAs and stroke and will explain the complex link between both. The miRNAs participate extensively in the pathophysiology following the stroke, including apoptosis, neuroinflammation, oxidative stress, blood-brain barrier (BBB) disruption and brain edema. The information about the stroke-miRNA system may be helpful for therapeutic and diagnostic methods in stroke treatment.
中风是全球最具破坏性的疾病之一。近年来，大量研究集中在 microRNAs（miRNAs）对中风的影响上，研究结果表明，miRNAs 的表达与中风的预后有关。在本研究中，我们回顾了有关 miRNAs 和中风的相关文章，并解释了两者之间复杂的联系。miRNAs 广泛参与中风后的病理生理学过程，包括细胞凋亡、神经炎症、氧化应激、血脑屏障（BBB）破坏和脑水肿。关于中风-miRNA 系统的信息可能有助于中风治疗的治疗和诊断方法。
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