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撤回:microRNA-129-5p 通过靶向 HMGB1-RAGE 信号通路对胶原酶诱导的脑出血大鼠模型再血管化的影响。

RETRACTED: Effect of microRNA-129-5p targeting HMGB1-RAGE signaling pathway on revascularization in a collagenase-induced intracerebral hemorrhage rat model.

机构信息

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China.

Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, PR China.

出版信息

Biomed Pharmacother. 2017 Sep;93:238-244. doi: 10.1016/j.biopha.2017.06.012. Epub 2017 Jun 20.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. An Expression of Concern for this article was previously published while an investigation was conducted (see related editorial: https://doi.org/10.1016/j.biopha.2022.113812). This retraction notice supersedes the Expression of Concern published earlier. Concern was raised about the reliability of the Western blot data in Figure 2A, which contain suspected image duplications within the β-actin blot, and appear to represent a distinct phenotype as found in many other publications, as detailed here: https://pubpeer.com/publications/83FD53A8F4C5B60E2187CBF9F29B01; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. Independent analysis confirmed these findings and also identified additional suspected image duplications within Figures 3 and 4A. The journal requested the corresponding author comment on these concerns and provide the associated raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.

摘要

本文已被撤回

请参阅 Elsevier 撤稿政策(http://www.elsevier.com/locate/withdrawalpolicy)。应主编要求撤回本文。在进行调查的同时,曾发表过一篇对此文的关注声明(见相关社论:https://doi.org/10.1016/j.biopha.2022.113812)。本撤稿通知取代了先前发表的关注声明。对图 2A 中的 Western blot 数据的可靠性提出了质疑,其中包含 β-肌动蛋白印迹中的疑似图像重复,并且似乎代表了许多其他出版物中发现的明显表型,如下所述:https://pubpeer.com/publications/83FD53A8F4C5B60E2187CBF9F29B01;以及此处:https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249。独立分析证实了这些发现,并在图 3 和 4A 中还发现了其他疑似图像重复。期刊要求通讯作者对这些问题发表评论并提供相关原始数据。作者未对此请求作出回应,因此主编决定撤回该文章。

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