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阿片生长因子及其受体系统：中风中抗氧化应激的一个新的有前景的靶点。

Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke.

作者信息

Xu Weilin, Yan Jun, Travis Zachary D, Lenahan Cameron, Gao Liansheng, Wu Haijian, Zheng Jingwei, Zhang Jianmin, Shao Anwen, Yu Jun

机构信息

Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China.

出版信息

Front Pharmacol. 2025 Jan 15;15:1352927. doi: 10.3389/fphar.2024.1352927. eCollection 2024.

DOI:10.3389/fphar.2024.1352927
PMID:39881878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11775478/
Abstract

The apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central nervous system (CNS). However, the distribution of the apelin/APJ system varies across different regions and subcellular organelles of the brain. Additionally, the neuroprotective effects of the apelin/APJ system have been reported to inhibit oxidative and nitrative stresses via various signaling pathways. Despite this, the clinical application of the apelin/APJ system remains distant, as apelin has numerous active forms and signaling pathways. The development of a range of drugs targeting the apelin/APJ system holds promise for treating stroke.

摘要

近年来，阿片肽/阿片肽受体（apelin/APJ）系统受到越来越多的关注。在本综述中，我们全面讨论了apelin/APJ系统在中风中的生理和病理机制。apelin/APJ系统在中枢神经系统（CNS）中广泛表达。然而，apelin/APJ系统在大脑的不同区域和亚细胞器中的分布有所不同。此外，据报道，apelin/APJ系统的神经保护作用可通过各种信号通路抑制氧化应激和硝化应激。尽管如此，由于apelin有多种活性形式和信号通路，apelin/APJ系统的临床应用仍很遥远。一系列针对apelin/APJ系统的药物的开发有望用于治疗中风。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/54f900a0ee40/fphar-15-1352927-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/73e530e16d44/FPHAR_fphar-2024-1352927_wc_abs.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/6fe9c7c6d373/fphar-15-1352927-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/f16fdd49397a/fphar-15-1352927-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/77263ce1b1e0/fphar-15-1352927-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/54f900a0ee40/fphar-15-1352927-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/73e530e16d44/FPHAR_fphar-2024-1352927_wc_abs.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/6fe9c7c6d373/fphar-15-1352927-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/f16fdd49397a/fphar-15-1352927-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/77263ce1b1e0/fphar-15-1352927-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/11775478/54f900a0ee40/fphar-15-1352927-g004.jpg

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