从三带喙库蚊中发现两种新型双链RNA病毒，它们可分类到双分病毒科内一个与感染节肢动物病毒不同的进化枝中。
Discovery of two novel totiviruses from Culex tritaeniorhynchus classifiable in a distinct clade with arthropod-infecting viruses within the family Totiviridae.
作者信息
Huang Yong, Guo Xiaofang, Zhang Shuyan, Zhao Qiumin, Sun Qiang, Zhou Hongnin, Zhang Jiusong, Tong Yigang
机构信息
Beijing Institute of Microbiology and Epidemiology, 20 Dong-Da Street, Fengtai District, Beijing, 100071, China.
Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Yunnan Institute of Parasitic Diseases, Pu'er, Yunnan, China.
出版信息
Arch Virol. 2018 Oct;163(10):2899-2902. doi: 10.1007/s00705-018-3871-1. Epub 2018 Jun 6.
Two double-stranded RNA viruses, named Culex tritaeniorhynchus totivirus NJ2 (CTV_NJ2) and NJ3 (CTV_NJ3), were discovered from wild-captured Culex tritaeniorhynchus mosquitoes. The complete genomes (7,624 and 7,612 bp in length) were obtained using RNA sequencing. Both CTV_NJ2 and CTV_NJ3 encode a putative capsid protein and an RNA-dependent RNA polymerase. The most similar strain to CTV_NJ2/3 is Omono River virus strain AK4 (ORV-AK4). The CP and RdRp identities of AK4 are different to CTV_NJ2 (84% and 87%) and CTV_NJ3 (47% and 62%). Phylogenetic analysis showed that taxonomically speaking CTV_NJ2/3 grouped within the unclassified Totiviridae and formed a distinct clade with other arthropod-infecting viruses.
从野外捕获的三带喙库蚊中发现了两种双链RNA病毒，分别命名为三带喙库蚊全病毒NJ2（CTV_NJ2）和NJ3（CTV_NJ3）。通过RNA测序获得了完整基因组（长度分别为7624和7612 bp）。CTV_NJ2和CTV_NJ3均编码一种假定的衣壳蛋白和一种RNA依赖的RNA聚合酶。与CTV_NJ2/3最相似的毒株是小诸川病毒毒株AK4（ORV-AK4）。AK4的CP和RdRp同一性与CTV_NJ2（84%和87%）和CTV_NJ3（47%和62%）不同。系统发育分析表明，从分类学上讲，CTV_NJ2/3归类于未分类的全病毒科，并与其他感染节肢动物的病毒形成一个独特的进化枝。
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