Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Epilepsia. 2018 Jun;59 Suppl 1:36-41. doi: 10.1111/epi.14046.
Sudden unexpected death in epilepsy (SUDEP) is a common cause of death in epilepsy and frequently occurs following generalized tonic-clonic seizures (GTCS). Non-electroencephalography (EEG) seizure detection systems using mobile sensor devices permit caregivers to assist patients during seizures and may reduce risks for complications of seizures such as injuries and SUDEP. We review changes in accelerometry, electrodermal activity, and heart rate associated with tonic-clonic seizures and their use in detection systems, including multimodal detectors. We reviewed current and past publications reporting data on linkage between GTCS, post-ictal generalized EEG suppression (PGES), and ventilatory dysfunction. The timing and duration of postictal immobility and respiratory dysfunction associated with convulsions help identify which patients might benefit the most from seizure monitoring and from benchmarks for the timing of seizure detection, caregiver alerting, and interventions.
癫痫性猝死（SUDEP）是癫痫的常见死因，常发生在全身性强直-阵挛发作（GTCS）之后。使用移动传感器设备的非脑电图（EEG）癫痫发作检测系统允许护理人员在发作期间协助患者，并可能降低癫痫发作并发症（如损伤和 SUDEP）的风险。我们回顾了与强直-阵挛发作相关的加速度计、皮肤电活动和心率的变化及其在检测系统中的应用，包括多模态检测器。我们回顾了目前和过去的出版物，报告了 GTCS、癫痫后广泛 EEG 抑制（PGES）和通气功能障碍之间联系的数据。与抽搐相关的发作后无反应和呼吸功能障碍的时间和持续时间有助于确定哪些患者最受益于癫痫监测以及癫痫发作检测、护理人员警报和干预的时间基准。
