炎症性肠病发病机制观点的演变

EVOLUTION OF VIEWS ON THE PATHOGENESIS OF INFLAMMATORY BOWEL DISEASE.

作者信息

Sizyakina L P, Tarasova G N, Dobaeva N V

出版信息

Eksp Klin Gastroenterol. 2016(8):57-61.

Abstract

Based on the literature overview and summarizing of practical experience we provides a current review of data regarding the epidemiology, etiology and pathogenesis of IBD. In this review authors focuse their attention on different links of the immune system, including the components of the innate immune system (macrophages, monocytes, neutrophils, dendritic cells), adaptive or acquired immunity (T and B cells), secreted mediators (cytokines and chemokines), as well as the cells of the intestinal epithelium and congenital limphoid cells, because according to modern concepts, elements of this system are the key factors of understanding the pathogenesis of IBD.

摘要

基于文献综述和实践经验总结，我们对炎症性肠病（IBD）的流行病学、病因和发病机制的现有数据进行了综述。在本综述中，作者将注意力集中在免疫系统的不同环节，包括固有免疫系统的组成部分（巨噬细胞、单核细胞、中性粒细胞、树突状细胞）、适应性或获得性免疫（T细胞和B细胞）、分泌介质（细胞因子和趋化因子），以及肠上皮细胞和先天性淋巴细胞，因为根据现代概念，该系统的这些要素是理解IBD发病机制的关键因素。