Kinani Aziz, Olivier Jérôme, Roumiguières Adrien, Bouchonnet Stéphane, Kinani Said
1 Division Recherche et Développement, Laboratoire National d'Hydraulique et Environnement (LNHE), Electricité de France (EDF), Chatou Cedex, France.
2 LCM, CNRS-École Polytechnique, Université Paris Saclay, Palaiseau, France.
Eur J Mass Spectrom (Chichester). 2018 Oct;24(5):375-383. doi: 10.1177/1469066718781302. Epub 2018 Jun 6.
A method for the analysis of 11 haloacetic acids in water samples has been developed. It involves enrichment of the target analytes from water samples by solid-phase extraction, derivatization to methyl esters, and gas chromatography coupled with tandem mass spectrometry determination. Gas chromatography conditions were optimized for a good separation of all haloacetic acids in a short runtime. Data were acquired in the multiple reaction monitoring mode. Six solid-phase extraction sorbents among the most widely used in environmental analysis were tested. Bakerbond SDB was retained because it has been shown to provide the best results for a large class of targeted haloacetic acids. The performances of the developed method have been assessed according to the French Standard NF T 90-210. The calibration curves for all the studied haloacetic acids had consistent slopes with r values > 0.99. Quantification limits between 0.01 and 0.50 µg l were achieved. Satisfactory repeatability (relative standard deviation ≤ 14.3%) and intermediate precision (relative standard deviation ≤ 15.7%) were obtained. Applied to the analysis of 15 untreated water samples collected from three rivers, the method allowed the detection of five haloacetic acids including monochloroacetic acid (in 100% of the samples, <0.5-1.85 µg l), dichloroacetic acid (87%, <0.05-0.22 µg l), trichloroacetic acid (93%, <0.05-0.52 µg l), dibromoacetic acid (53%, <0.01-0.40 µg l), tribromoacetic acid (20%, <0.05-0.14 µg l), and bromodichloroacetic acid (6%, < 0.05 µg l).
已开发出一种分析水样中11种卤乙酸的方法。该方法包括通过固相萃取从水样中富集目标分析物、衍生化为甲酯以及气相色谱-串联质谱测定。优化了气相色谱条件，以便在短运行时间内实现所有卤乙酸的良好分离。数据在多反应监测模式下采集。测试了环境分析中最常用的六种固相萃取吸附剂。保留了Bakerbond SDB，因为它已被证明对一大类目标卤乙酸能提供最佳结果。已根据法国标准NF T 90 - 210评估了所开发方法的性能。所有研究的卤乙酸的校准曲线斜率一致，r值>0.99。实现了0.01至0.50 μg l的定量限。获得了令人满意的重复性（相对标准偏差≤14.3%）和中间精密度（相对标准偏差≤15.7%）。将该方法应用于从三条河流采集的15个未处理水样的分析，检测到了五种卤乙酸，包括一氯乙酸（在100%的样品中，<0.5 - 1.85 μg l）、二氯乙酸（87%，<0.05 - 0.22 μg l）、三氯乙酸（93%，<0.05 - 0.52 μg l）、二溴乙酸（53%，<0.01 - 0.40 μg l）、三溴乙酸（20%，<0.05 - 0.14 μg l）和溴二氯乙酸（6%，<0.05 μg l）。
