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在啮齿动物炎性疼痛模型中，固绿FCF减轻疼痛超敏反应并下调脊髓P2X4表达水平和促炎细胞因子水平。

Fast Green FCF Alleviates Pain Hypersensitivity and Down-Regulates the Levels of Spinal P2X4 Expression and Pro-inflammatory Cytokines in a Rodent Inflammatory Pain Model.

作者信息

Xu Fang, Yang Jing, Lu Fan, Liu Rongjun, Zheng Jinwei, Zhang Junfang, Cui Wei, Wang Chuang, Zhou Wenhua, Wang Qinwen, Chen Xiaowei, Chen Junping

机构信息

Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo University, Ningbo, China.

Department of Anesthesiology, Ningbo No. 2 Hospital, Ningbo, China.

出版信息

Front Pharmacol. 2018 May 23;9:534. doi: 10.3389/fphar.2018.00534. eCollection 2018.

DOI:10.3389/fphar.2018.00534
PMID:29875666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5974208/
Abstract

Fast Green FCF (FGF), a biocompatible dye, recently drew attention as a potential drug to treat amyloid-deposit diseases due to its effects against amyloid fibrillogenesis and a high degree of safety. However, its role in inflammatory pain is unknown. Our study aimed to investigate the effect of FGF in the inflammatory pain model induced by complete Freund's adjuvant (CFA) and to identify the associated mechanisms. We found that systemic administration of FGF reversed mechanical and thermal pain hypersensitivity evoked by CFA in a dose-dependent manner. FGF treatment decreased purinergic spinal P2X4 expression in the spinal cord of CFA-inflamed mice. FGF also down-regulated spinal and peripheral pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6)], but did not alter the spinal level of nerve growth factor (NGF) or brain-derived neurotrophic factor (BDNF). In conclusion, our results suggest the potential of FGF for controlling the progress of inflammatory pain.

摘要

固绿FCF（FGF）是一种生物相容性染料，由于其对淀粉样纤维形成的抑制作用和高度安全性，最近作为一种治疗淀粉样沉积疾病的潜在药物受到关注。然而，其在炎性疼痛中的作用尚不清楚。我们的研究旨在探讨FGF在完全弗氏佐剂（CFA）诱导的炎性疼痛模型中的作用，并确定相关机制。我们发现，全身给药FGF可剂量依赖性地逆转CFA诱发的机械性和热痛超敏反应。FGF治疗降低了CFA炎症小鼠脊髓中嘌呤能脊髓P2X4的表达。FGF还下调了脊髓和外周促炎细胞因子[肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）]，但未改变脊髓神经生长因子（NGF）或脑源性神经营养因子（BDNF）的水平。总之，我们的结果表明FGF具有控制炎性疼痛进展的潜力。

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