The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan.
Chem Commun (Camb). 2018 Jun 21;54(51):7074-7077. doi: 10.1039/c8cc02393j.
We have reported bicyclic and tricyclic C-C mismatch-binding ligands that selectively bind to CCG trinucleotide repeat (TNR) DNAs. Bivalent interaction and enlarging the aromatic ring system of the cytosine-recognition unit led to the ligand binding to CCG TNRs accompanied by the formation of stable ligand-CCG TNR complexes and a large conformational change.
我们曾报道过二环和三环的 C-C 错配结合配体，它们能选择性地结合 CCG 三核苷酸重复（TNR）DNA。双价相互作用和增大胞嘧啶识别单元的芳环系统，导致配体与 CCG TNR 结合，同时形成稳定的配体-CCG TNR 复合物和大的构象变化。
