Department of General Surgery, University of Alberta, University of Alberta Hospital, 2D4.41 W.M.C., 8440-112 Street, Edmonton, AB, T6G 2B7, Canada.
Department of Oncology, University of Alberta, Edmonton, AB, Canada.
Cancer Chemother Pharmacol. 2018 Jul;82(1):1-29. doi: 10.1007/s00280-018-3614-8. Epub 2018 Jun 6.
Use of cross-sectional imaging to identify whole-body lean soft-tissue mass has recently emerged as an attractive prognostic factor for chemotherapy toxicities. Beyond that, there is increasing interest in use of lean soft-tissue mass as a more accurate method for dosing chemotherapy, as compared to body surface area. In this review, we summarize the current evidence that supports interactions between skeletal muscle and chemotherapy, the role of lean soft tissue in predicting chemotherapy toxicities and potential use of an alternate method of chemotherapeutic dosing, all based on quantification of skeletal muscle mass by computed tomography.
使用横断面成像来识别全身瘦体组织质量最近已成为预测化疗毒性的一个有吸引力的预后因素。除此之外，人们越来越感兴趣的是将瘦体组织质量作为一种比体表面积更准确的化疗剂量方法。在这篇综述中，我们总结了目前支持肌肉骨骼与化疗相互作用的证据、瘦体组织在预测化疗毒性中的作用以及基于计算机断层扫描对骨骼肌质量进行定量的潜在替代化疗剂量方法的使用。
