Rodríguez-Sánchez Isabel, Carnicero-Carreño José Antonio, Álvarez-Bustos Alejandro, García-García Francisco José, Rodríguez-Mañas Leocadio, Coelho-Júnior Hélio José
Geriatrics Department, Hospital Universitario Clínico San Carlos, 28905 Madrid, Spain.
Instituto de Investigación Sanitaria Hospital Clínico San Carlos, 28029 Madrid, Spain.
Nutrients. 2025 Apr 22;17(9):1400. doi: 10.3390/nu17091400.
Malnutrition may increase the risk of frailty in individuals with musculoskeletal pain. However, this scenario has not been explored in detail. As such, the present study was conducted to examine the effects of malnutrition on the risk of incident and worsening frailty in community-dwelling older adults with musculoskeletal pain. Data from 895 community-dwelling older adults participating in the Toledo Study of Healthy Ageing who reported experiencing musculoskeletal pain during the month preceding data collection (mean age: 74.9 ± 5.6 years) were analyzed. Pain characteristics (i.e., intensity, locations, and treatment) were assessed based on self-reported information regarding the last month. Malnutrition was operationalized according to the GLIM criteria. Frailty status was assessed at baseline and at follow-up (~2.99 years), according to the Frailty Phenotype paradigm, operationalized through the Frailty Trait Scale 5. Associations between the variables were tested using logistic regression analyses adjusted for many covariates established a priori. Malnutrition increased the risk of frailty (odds ratio [OR] = 4.41) and worsening of frailty status (OR = 6.25) in the participants who used ≥2 groups of painkillers in comparison to their non-undernourished peers. The findings of the present study indicate that malnutrition increases the risk of both developing and worsening frailty in older adults with musculoskeletal disorders. In particular, an increased risk of incident frailty and worsening frailty status was found in undernourished individuals using ≥2 analgesic drugs. Our results suggest that nutritional assessment should be included in the evaluation of old people living with musculoskeletal pain.
营养不良可能会增加肌肉骨骼疼痛患者出现身体虚弱的风险。然而，这一情况尚未得到详细研究。因此，本研究旨在探讨营养不良对社区居住的患有肌肉骨骼疼痛的老年人发生身体虚弱及身体虚弱加重风险的影响。对895名参与托莱多健康老龄化研究的社区居住老年人的数据进行了分析，这些老年人在数据收集前一个月报告有肌肉骨骼疼痛（平均年龄：74.9±5.6岁）。根据关于上个月的自我报告信息评估疼痛特征（即强度、部位和治疗情况）。根据全球营养不良领导倡议（GLIM）标准确定营养不良情况。根据衰弱表型范式，通过衰弱特征量表5在基线和随访时（约2.99年）评估衰弱状态。使用针对许多先验确定的协变量进行调整的逻辑回归分析来检验变量之间的关联。与非营养不良的同龄人相比，在使用≥2组止痛药的参与者中，营养不良增加了身体虚弱的风险（优势比[OR]=4.41）和身体虚弱状态恶化的风险（OR=6.25）。本研究结果表明，营养不良会增加患有肌肉骨骼疾病的老年人发生身体虚弱和身体虚弱加重的风险。特别是，在使用≥2种镇痛药的营养不良个体中，发现发生身体虚弱和身体虚弱状态恶化的风险增加。我们的结果表明，在对患有肌肉骨骼疼痛的老年人进行评估时应包括营养评估。
