Novel Methods for Family-Based Genetic Studies.

The recent development of microarray and sequencing technology allows identification of disease susceptibility genes. Although the genome-wide association studies (GWAS) have successfully identified many genetic markers related to human diseases, the traditional statistical methods are not powerful to detect rare genetic markers. The rare genetic markers are usually grouped together and tested at the set level. One of such methods is the sequence kernel association test (SKAT), which has been commonly used in the rare genetic marker analysis. In recent publications, SKAT has been extended to be applicable for family-based rare variant analysis. Here, I present three published statistical approaches for family-based rare variant analysis for: 1. continuous traits, 2. binary traits, and 3. multiple correlated traits.