Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering , Changzhou University , Changzhou 213164 , P. R. China.
Org Lett. 2018 Jun 15;20(12):3710-3713. doi: 10.1021/acs.orglett.8b01584. Epub 2018 Jun 7.
A copper-catalyzed asymmetric formal [4 + 2]-cycloaddition of copper-allenylidenes and hexahydro-1,3,5-triazines has been developed, providing chiral tetrahydroquinazolines in moderate to good yields and with high enantioselectivities for most cases (up to 88% yield and 98% ee).
发展了一种铜催化的铜烯丙基和六氢-1,3,5-三嗪的不对称形式[4 + 2]-环加成反应，为大多数情况下（高达 88%的产率和 98%的对映选择性）提供了中等至良好产率和高对映选择性的手性四氢喹唑啉。
