赞成与反对观点辩论：2017 年美国胸科学会国际会议上关于肺动脉高压发病机制的当前争议。
A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017.
机构信息
Institute of Physiology, Charité-Universitaetsmedizin Berlin, Berlin , Germany.
Keenan Research Centre for Biomedical Science at Saint Michael's , Toronto, Ontario , Canada.
出版信息
Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L502-L516. doi: 10.1152/ajplung.00150.2018. Epub 2018 Jun 7.
Abstract
The following review summarizes the pro-con debate about current controversies regarding the pathogenesis of pulmonary arterial hypertension (PAH) that took place at the American Thoracic Society Conference in May 2017. Leaders in the field of PAH research discussed the importance of the immune system, the role of hemodynamic stress and endothelial apoptosis, as well as bone morphogenetic protein receptor-2 signaling in PAH pathogenesis. Whereas this summary does not intend to resolve obvious conflicts in opinion, we hope that the presented arguments entice further discussions and draw a new generation of enthusiastic researchers into this vibrant field of science to bridge existing gaps for a better understanding and therapy of this fatal disease.
摘要
以下综述总结了 2017 年 5 月在美国胸科学会会议上关于肺动脉高压（PAH）发病机制的当前争议的利弊辩论。PAH 研究领域的领导者讨论了免疫系统、血流动力学应激和内皮细胞凋亡以及骨形态发生蛋白受体 2 信号在 PAH 发病机制中的重要性。虽然本综述无意解决明显的意见冲突，但我们希望提出的论点能激发进一步的讨论，并吸引新一代热衷于研究的人员进入这一充满活力的科学领域，以弥合现有差距，更好地理解和治疗这种致命疾病。
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