Cooper S J, Jackson A, Morgan R, Carter R
Neuropeptides. 1985 Feb;5(4-6):345-8. doi: 10.1016/0143-4179(85)90024-1.
Nondeprived adult rats were familiarized with a highly palatable diet (powdered small animal diet mixed with sweetened condensed milk and water). The palatability of food was such that it induced vigorous feeding responses, 15-20 g food consumed within the first 30 min of access. In partially-satiated male rats, the kappa receptor agonists EKC and U-50,488 (subcutaneously administered) produced large increases in food consumption in the first 30 min of access, post-injection. In experiments with naloxone and WIN 44,441-3, we found that the effects of naloxone (0.01-10 mg/kg; S.C.) were crucially dependent on the sex and dietary history of the animals. Male, obese rats were most sensitive to naloxone's anorectic effect. Lean females were completely insensitive. WIN 44,441-3 (0.01-10 mg/kg, S.C.) had no effect on food intake in any group of animals.
未禁食的成年大鼠熟悉了一种美味的食物（将粉状小动物饲料与甜炼乳和水混合）。食物的适口性很强，能引发强烈的进食反应，在开始进食的前30分钟内会消耗15 - 20克食物。在部分饱腹的雄性大鼠中，κ受体激动剂EKC和U - 50,488（皮下注射）在注射后开始进食的前30分钟内使食物摄入量大幅增加。在使用纳洛酮和WIN 44,441 - 3的实验中，我们发现纳洛酮（0.01 - 10毫克/千克；皮下注射）的作用关键取决于动物的性别和饮食史。雄性肥胖大鼠对纳洛酮的厌食作用最为敏感。瘦雌性大鼠则完全不敏感。WIN 44,441 - 3（0.01 - 10毫克/千克，皮下注射）对任何一组动物的食物摄入量均无影响。
