Williams L L, Lowery H W, Glaser R
Pediatrics. 1985 Jun;75(6):1020-7.
Sudden, permanent hearing loss developed in three young patients. In an attempt to determine a viral etiology, their humoral and cell-mediated responses to a panel of seven viruses linked to deafness and altered immunity were measured. Although a specific viral cause was not determined, a mild Epstein-Barr virus infection was documented for each patient. It had preceded their hearing loss onset by 1 to 4 months. Evidence of altered cell-mediated responses to Epstein-Barr virus antigens was found in each patient. It is proposed that, in certain susceptible individuals, a temporary cellular immunosuppression, which accompanies normal recovery from Epstein-Barr virus infection, may provide an opportunity for a viral invasion of, or a latent viral reactivation in, the inner ear. This invasion or reactivation leads to deafness.
三名年轻患者突然出现永久性听力丧失。为了确定病毒病因，检测了他们对一组与耳聋和免疫改变相关的七种病毒的体液免疫和细胞介导免疫反应。虽然未确定具体的病毒病因，但记录显示每名患者均有轻度的爱泼斯坦-巴尔病毒感染。该感染在其听力丧失发作前1至4个月出现。每名患者均发现对爱泼斯坦-巴尔病毒抗原的细胞介导免疫反应改变的证据。有人提出，在某些易感个体中，爱泼斯坦-巴尔病毒感染正常恢复过程中伴随的暂时性细胞免疫抑制，可能为病毒侵入内耳或内耳潜伏病毒重新激活提供机会。这种侵入或重新激活会导致耳聋。
