Sy Andrew, Cheng Jerry, Cooper Robert, Mueller Lisa
Kaiser Permanente Southern California.
J Pediatr Hematol Oncol. 2019 Jan;41(1):e41-e43. doi: 10.1097/MPH.0000000000001230.
Vincristine (VCR) is a common chemotherapeutic agent used in the treatment of multiple types of pediatric tumors. VCR's adverse effects are well documented and commonly involve peripheral neuropathy via axonal degeneration. Neuropathic severity is dose-dependent, with sensory deficits occurring with as little as 4 mg cumulative dose. Severe peripheral neuropathy is generally rare, but its effects become additive when given to patients with undiagnosed hereditary peripheral neuropathy such as Charcot-Marie-Tooth. We report a case of an effect of VCR administration given to a patient who developed grade 4 neuropathy and was found to be a carrier of Charcot-Marie-Tooth disease type 4.
长春新碱（VCR）是一种常用于治疗多种儿童肿瘤的化疗药物。VCR的不良反应已有充分记录，通常会通过轴突变性导致周围神经病变。神经病变的严重程度与剂量相关，累积剂量低至4毫克时就会出现感觉缺陷。严重的周围神经病变一般较为罕见，但给予未确诊的遗传性周围神经病变患者（如夏科-马里-图斯病）时，其影响会叠加。我们报告了一例给予VCR治疗的患者发生4级神经病变的病例，该患者被发现是4型夏科-马里-图斯病的携带者。
