Igarashi M, Thompson E I, Rivera G K
Department of Pediatrics, University of Tennessee, USA.
Med Pediatr Oncol. 1995 Aug;25(2):113-6. doi: 10.1002/mpo.2950250212.
A patient with Ewing's sarcoma and demyelinating type Charcot-Marie-Tooth disease (CMT) developed severe neuropathy after receiving a total vincristine dose of 6 mg. Recovery was slow and incomplete. A second patient with axonal type CMT developed moderate neuropathy but tolerated extended vincristine administration and recovered quickly. Possible underlying neuropathy should be excluded before vincristine treatment is begun by careful examination including inspection of the feet, followed by electrophysiologic studies as indicated. In demyelinating CMT, vincristine should be avoided; in axonal form cautious use may be considered.
一名患有尤因肉瘤和脱髓鞘型夏科-马里-图思病（CMT）的患者在接受了总量为6毫克的长春新碱后出现了严重的神经病变。恢复缓慢且不完全。另一名患有轴索性CMT的患者出现了中度神经病变，但耐受了长春新碱的长期给药且恢复迅速。在开始长春新碱治疗前，应通过仔细检查（包括足部检查）并根据需要进行电生理研究，排除可能存在的潜在神经病变。对于脱髓鞘型CMT，应避免使用长春新碱；对于轴索型CMT，可考虑谨慎使用。
