Department of Physiotherapy, University of Malaga, Spain.
Department of Physiotherapy, University of Malaga, Spain; School of Clinical Science, Faculty of Health Science, Queensland University Technology, Australia.
Psychiatry Res. 2018 Sep;267:19-24. doi: 10.1016/j.psychres.2018.05.055. Epub 2018 May 23.
Anti-psychotic medication has emerged as the primary medical treatment for people with severe mental illness, despite the great risks involved in the use of this medication. In addition, this population suffers from problems of obesity, sedentary lifestyle and poor physical fitness, which is aggravated by the use of this type of medication. The objective of this study is to explore the influence of the most commonly used antipsychotics in this population (Olanzapine and Risperidone) on physical activity and the physical fitness of people with severe mental illness. Sixty-two people between 26 and 61 years of age with severe mental illness were assessed. All participants were evaluated with a battery of 11 physical tests to assess their physical fitness and with the IPAQ-short version questionnaire to determine their level of physical activity. The doses of Risperidone and Olanzapine were also evaluated in all participants. Significant differences were found for physical activity, with higher levels reported in those patients with severe mental illness who did not take any of these medications. Regarding physical fitness, significant differences were only found for the consumption of Risperidone, with better physical fitness levels seen in patients who did not consume this medication; on the other hand, for the consumption of Olanzapine, differences were found in muscular strength, balance and aerobic condition with better values in non-Olanzapine consumers compared with Olanzapine consumers.
抗精神病药物已成为严重精神疾病患者的主要医学治疗方法，尽管这种药物的使用存在很大风险。此外，这一人群还存在肥胖、久坐不动的生活方式和身体状况不佳等问题，而这种类型的药物的使用则加剧了这些问题。本研究的目的是探讨在这一人群中最常用的抗精神病药物（奥氮平和利培酮）对身体活动和严重精神疾病患者身体状况的影响。评估了 62 名年龄在 26 岁至 61 岁之间的严重精神疾病患者。所有参与者都接受了一套 11 项身体测试，以评估他们的身体状况，并接受 IPAQ-short 版问卷，以确定他们的身体活动水平。还评估了所有参与者的利培酮和奥氮平剂量。在身体活动方面发现了显著差异，那些未服用这些药物的严重精神疾病患者报告的身体活动水平更高。关于身体状况，仅在利培酮的消耗方面发现了显著差异，未服用该药物的患者身体状况更好；另一方面，对于奥氮平的消耗，在肌肉力量、平衡和有氧条件方面存在差异，与奥氮平的消耗相比，非奥氮平的消耗者的数值更好。
