Hashmi Atif Ali, Hussain Zubaida Fida, Irfan Muhammad, Khan Erum Yousuf, Faridi Naveen, Naqvi Hanna, Khan Amir, Edhi Muhammad Muzzammil
Liaquat National Hospital and Medical College, Karachi, Pakistan.
Kandahar University, Kandahar, Afghanistan.
BMC Urol. 2018 Jun 7;18(1):59. doi: 10.1186/s12894-018-0373-0.
Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Frequency of over expression in bladder cancer has not been studied in our population; therefore we aimed to evaluate the frequency and prognostic significance of EGFR immunohistochemical expression in locoregional population.
We performed EGFR immunohistochemistry on 126 cases of bladder cancer and association of EGFR expression with tumor grade, lamina propria invasion, deep muscle invasion and recurrence of disease was evaluated.
High EGFR expression was noted in 26.2% (33 cases), 15.1% (19 cases) and 58.7% (74 cases) revealed low and no EGFR expression respectively. Significant association of EGFR expression was noted with tumor grade, lamina propria invasion, deep muscle invasion and recurrence status while no significant association was seen with age, gender and overall survival. Kaplan- Meier curves revealed significant association of EGFR expression with recurrence while no significant association was seen with overall survival.
Significant association of EGFR overexpression with tumor grade, muscularis propria invasion and recurrence signifies its prognostic value; therefore EGFR can be used as a prognostic biomarker in Urothelial bladder carcinoma.
表皮生长因子受体（EGFR）在许多人类癌症中已显示出异常表达，并被认为是预后不良的标志物。在我们的人群中尚未研究膀胱癌中EGFR过表达的频率；因此，我们旨在评估局部区域人群中EGFR免疫组化表达的频率及其预后意义。
我们对126例膀胱癌进行了EGFR免疫组化检测，并评估了EGFR表达与肿瘤分级、固有层浸润、深层肌肉浸润和疾病复发之间的关系。
26.2%（33例）显示EGFR高表达，15.1%（19例）显示低EGFR表达，58.7%（74例）显示无EGFR表达。EGFR表达与肿瘤分级、固有层浸润、深层肌肉浸润和复发状态之间存在显著相关性，而与年龄、性别和总生存期无显著相关性。Kaplan-Meier曲线显示EGFR表达与复发之间存在显著相关性，而与总生存期无显著相关性。
EGFR过表达与肿瘤分级、肌层浸润和复发之间的显著相关性表明了其预后价值；因此，EGFR可作为尿路上皮膀胱癌的预后生物标志物。
