Lutzeyer W, Rübben H, Dahm H
J Urol. 1982 Feb;127(2):250-2. doi: 10.1016/s0022-5347(17)53725-8.
A retrospective study of 315 patients with superficial transitional cell carcinoma (stages Ta to T2) and an adequate followup of 3 years or longer is reported. Transurethral resection was done in 80 per cent of the patients and open excision or resection was done in 20 per cent for cure or control. We herein demonstrate that, in addition to grade and stage, multifocal tumor growth and whether the tumor is primary or recurrent influence the frequency of recurrences and tumor progression. The over-all recurrence rate after resection of stages Ta, T1 and T2 tumors within 3 years was 60 per cent. Recurrences after a primary tumor were noted in 45 per cent of the patients and were followed by a second recurrence in 84 per cent, with solitary tumors occurring in 46 and multifocal tumors in 73 per cent. Tumor progression was observed in 24 per cent of patients with solitary tumors, 44 per cent of those with multifocal tumors, 20 to 25 per cent of those with primary and recurrent stage Ta and primary stage T1 tumors, and 56 per cent of those with recurrent stage T1 tumors. Therefore, when therapy is planned stage, grade, multifocal tumor growth and whether the tumor is primary or recurrent should be considered. Stage Ta tumors can be treated sufficiently by transurethral resection even in the case of several recurrences. More aggressive therapy should be considered when multifocal or recurrent stage T1 or T2 tumors recur as invasive carcinomas.
报告了一项对315例浅表性移行细胞癌（Ta至T2期）患者进行的回顾性研究，且有3年或更长时间的充分随访。80%的患者接受了经尿道切除术，20%的患者接受了开放性切除或切除术以治愈或控制病情。我们在此证明，除了分级和分期外，多灶性肿瘤生长以及肿瘤是原发性还是复发性也会影响复发频率和肿瘤进展。Ta、T1和T2期肿瘤切除后3年内的总体复发率为60%。45%的患者在原发性肿瘤后出现复发，其中84%的患者随后出现第二次复发，单发肿瘤患者占46%，多灶性肿瘤患者占73%。在单发肿瘤患者中观察到24%的肿瘤进展，多灶性肿瘤患者中为44%，原发性和复发性Ta期及原发性T1期肿瘤患者中为20%至25%，复发性T1期肿瘤患者中为56%。因此，在规划治疗方案时，应考虑分期、分级、多灶性肿瘤生长以及肿瘤是原发性还是复发性。即使Ta期肿瘤出现多次复发经尿道切除术也可充分治疗。当多灶性或复发性T1或T2期肿瘤复发为浸润性癌时，应考虑更积极的治疗。
