Arfaoui Amira Toumi, Mejri S, Belhaj R, Karkni W, Chebil M, Rammeh S
a Department of Pathology , Charles Nicolle University Hospital , Tunis , Tunisia.
b Department of Urology , Charles Nicolle University Hospital , Tunis , Tunisia.
J Immunoassay Immunochem. 2016;37(4):359-67. doi: 10.1080/15321819.2016.1146757.
We studied epidermal growth factor receptor (EGFR) expression profile in urothelial bladder carcinoma (UBC) which is a complex and heterogeneous disease with a large spectrum of histological aspects and deadly potential. Using immunohistochemistry (IHC), all GI tumors and pTa cases showed a low expression profile of EGFR. However, we note that when the stage of disease is advanced, tumors over-express EGFR. Indeed, 5% and 25% of GII and GIII tumors over-expressed EGFR, respectively. Further, 0% of pTa, 9,5% of pT1, 15% of pT2, 50% of pT3, and 90% of pT4 tumors were shown to be high EGFR expression (HEE). Moreover, we found a statistically significant correlation between the EGFR over-expression and grade and stage (P < 0.05). Thus, EGFR over-expression could be a potential prognostic marker to predict poor outcome in Tunisian patients with UBC.
我们研究了膀胱尿路上皮癌（UBC）中表皮生长因子受体（EGFR）的表达情况，膀胱尿路上皮癌是一种复杂的异质性疾病，具有广泛的组织学特征和致命潜力。通过免疫组织化学（IHC）检测发现，所有胃肠道肿瘤和pTa病例的EGFR表达水平较低。然而，我们注意到，当疾病进展到晚期时，肿瘤会过度表达EGFR。事实上，GII级和GIII级肿瘤中分别有5%和25%过度表达EGFR。此外，pTa肿瘤中EGFR高表达（HEE）的比例为0%，pT1为9.5%，pT2为15%，pT3为50%，pT4为90%。而且，我们发现EGFR过度表达与肿瘤分级和分期之间存在统计学显著相关性（P < 0.05）。因此，EGFR过度表达可能是预测突尼斯UBC患者预后不良的潜在预后标志物。
