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腭裂一期修复术后实现低腭瘘发生率面临的挑战:乌干达一家机构的经验

Challenges to achieving low palatal fistula rates following primary cleft palate repair: experience of an institution in Uganda.

作者信息

Katusabe Josephine Linda, Hodges Andrew, Galiwango George William, Mulogo Edgar M

机构信息

Comprehensive Rehabilitation Services Uganda (CoRSU) Hospital, P.O.Box 46, Kisubi, Uganda.

Mbarara University of Science and Technology, P.O.Box 1410, Mbarara, Uganda.

出版信息

BMC Res Notes. 2018 Jun 7;11(1):358. doi: 10.1186/s13104-018-3459-6.

Abstract

OBJECTIVE

To determine frequency of palatal fistula following primary cleft palate repair and the associated factors as a measure of cleft palate repair outcome and its challenges at a cleft centre in Uganda.

RESULTS

Between May and December 2016, 54 children with cleft palate were followed up at Comprehensive Rehabilitation services of Uganda (CoRSU) hospital, from time of primary cleft palate repair until at least 3 months postoperative to determine whether they developed palatal fistula or not. Frequency of palatal fistula was 35%. Factors associated with increased fistula formation were cleft width wider than 12 mm (p = 0.006), palatal index greater than 0.4 (p = 0.046), presence of malnutrition at initial outpatient assessment (p = 0.0057) and at time of surgery (p = 0.008), two-stage palate repair (p = 0.005) and postoperative infection (p = 0.003). Severe clefting (palatal index greater than 0.4) was seen in 74% of patients and malnutrition (Low weight for age) seen in 48% of patients. Palatal fistula rates at our institution were high compared to reports in literature. The high proportions of severe clefting and malnutrition observed in our population that was also poor and unable to afford feeding supplements increased likelihood of fistula formation and posed challenges to achieving low fistula rates in our setting.

摘要

目的

在乌干达的一个腭裂治疗中心,确定一期腭裂修复术后腭瘘的发生率及其相关因素,以此作为腭裂修复效果及其面临挑战的衡量指标。

结果

2016年5月至12月期间,对乌干达综合康复服务医院(CoRSU)的54例腭裂患儿进行了随访,从一期腭裂修复时起直至术后至少3个月,以确定他们是否发生腭瘘。腭瘘的发生率为35%。与瘘管形成增加相关的因素包括腭裂宽度大于12毫米(p = 0.006)、腭指数大于0.4(p = 0.046)、初次门诊评估时存在营养不良(p = 0.0057)以及手术时存在营养不良(p = 0.008)、两阶段腭裂修复(p = 0.005)和术后感染(p = 0.003)。74%的患者存在严重腭裂(腭指数大于0.4),48%的患者存在营养不良(年龄别体重低)。与文献报道相比,我们机构的腭瘘发生率较高。在我们这个贫穷且无力负担营养补充剂的人群中,观察到的严重腭裂和营养不良的高比例增加了瘘管形成的可能性,并给在我们的环境中实现低瘘管发生率带来了挑战。

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