INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response Team, Lyon, F-69000, France.
University Lyon 1, Villeurbanne, F-69000, France.
Sci Rep. 2018 Jun 7;8(1):8724. doi: 10.1038/s41598-018-27057-1.
Recent studies have shown that transcranial direct current stimulation (tDCS) may reduce craving and smoking. However, little is known regarding brain correlates of these behavioral changes. We aimed to evaluate whether 10 sessions of tDCS modulate cigarette consumption, craving and brain reactivity to smoking cues in subjects with tobacco use disorder (TUD). In a double blind parallel-arms study, 29 subjects with TUD who wished to quit smoking were randomly assigned to receive 10 sessions of either active or sham tDCS applied with the anode over the right dorsolateral prefrontal cortex (DLPFC) and a large cathode over the left occipital region. As compared to sham, active tDCS significantly reduced smoking craving and increased brain reactivity to smoking-cues within the right posterior cingulate, as measured with a functional magnetic resonance imaging event-related paradigm. However, we failed to find a significant difference between active and sham groups regarding the self-reported number of cigarettes smoked and the exhaled carbon monoxide during one month. These findings suggested that 10 sessions of tDCS over the right DLPFC may reduce craving by modulating activity within the resisting-to-smoke network but might not be significantly more effective than sham to decrease cigarette consumption.
最近的研究表明，经颅直流电刺激（tDCS）可能会减少吸烟的渴望和吸烟量。然而，对于这些行为变化的大脑相关性知之甚少。我们旨在评估 10 次 tDCS 是否可以调节有吸烟障碍（TUD）的受试者的吸烟量、吸烟渴望和对吸烟线索的大脑反应。在一项双盲平行臂研究中，29 名有戒烟意愿的 TUD 患者被随机分配接受 10 次真或假 tDCS 治疗，阳极置于右侧背外侧前额叶皮质（DLPFC），大阴极置于左侧枕叶区域。与假刺激相比，真刺激显著降低了吸烟渴望，并增加了对与吸烟相关的线索的大脑反应，这是通过功能磁共振成像事件相关范式测量的。然而，我们未能发现真刺激和假刺激组在一个月内自我报告的吸烟量和呼出的一氧化碳之间有显著差异。这些发现表明，10 次右侧 DLPFC 的 tDCS 可能通过调节抗拒吸烟网络内的活动来减少吸烟渴望，但与假刺激相比，它可能并不更有效地减少吸烟量。
