Faculty of Medicine, King Saud University, Riyadh Saudi Arabia.
Laboratory of Canada Research Chair in Cognitive Neuroscience, CERVO Brain Research Center, Medical School, Laval University, Quebec, Canada.
PLoS One. 2019 Feb 14;14(2):e0212312. doi: 10.1371/journal.pone.0212312. eCollection 2019.
Recent studies reported that transcranial direct current stimulation (tDCS) applied over the dorsolateral prefrontal cortex (DLPFC) reduced craving and cigarette smoking. We aimed to evaluate whether 3 sessions of tDCS over the DLPFC modulate cigarette smoking which is a critical factor in tobacco smokers.
In a double-blinded, sham-controlled, parallel experimental study, 22 participants who wished to quit smoking received tDCS with the cathodal over the right DLPFC and anodal over the left DLPFC based on the 10-20 EEG international system (F4, F3) at an intensity of 1.5 mA for 20 minutes during three consecutive days. For sham stimulation, the electrodes placement was the same as for the active stimulation.
For the short time interval (8 days after the end of the tDCS regimen), the number of smoked cigarettes was reduced similarly in the active and sham groups (p < 0.001). Also, at the long time-interval (4 months after the end of the tDCS regimen) as compared to pre-tDCS, there was no significant difference in the number of smoked cigarettes in the active (p = 0.806) or the sham (p = 0.573) groups. Overall, there were no statistically significant differences between the active and sham tDCS groups on cigarette smoking.
These findings suggested that 3 sessions of tDCS over the right and left DLPFC may reduce number of smoked cigarettes for short-time period but might not be significantly more effective than sham to decrease cigarette smoking.
最近的研究报告称，经颅直流电刺激（tDCS）作用于背外侧前额叶皮层（DLPFC）可减少烟瘾和吸烟。我们旨在评估 3 次 DLPFC 上的 tDCS 是否会调节吸烟，这是烟草吸烟者的一个关键因素。
在一项双盲、假对照、平行实验研究中，22 名希望戒烟的参与者接受了 tDCS 治疗，阴极置于右侧 DLPFC，阳极置于左侧 DLPFC，基于 10-20 EEG 国际系统（F4、F3），强度为 1.5 mA，连续 3 天每天 20 分钟。对于假刺激，电极的放置与主动刺激相同。
在短时间间隔（tDCS 疗程结束后 8 天），主动组和假刺激组的吸烟量减少相似（p<0.001）。此外，在长时间间隔（tDCS 疗程结束后 4 个月）与 tDCS 前相比，主动组（p=0.806）和假刺激组（p=0.573）的吸烟量均无显著差异。总的来说，主动和假 tDCS 组之间的吸烟量没有统计学上的显著差异。
这些发现表明，3 次右侧和左侧 DLPFC 的 tDCS 可能会在短时间内减少吸烟量，但与假刺激相比，可能不会显著更有效地减少吸烟。
