Haupt Sue, Haupt Ygal
Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia.
Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia.
F1000Res. 2017 Nov 22;6:2041. doi: 10.12688/f1000research.12682.1. eCollection 2017.
Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection.
对人类肿瘤发生至关重要的天然保护机制由动态蛋白p53精心调控。p53最具特征的功能与其细胞应激反应相关。在本综述中，我们探讨了对p53活性及其功能后果的新见解。我们比较了人类和大象体内的p53，以寻找癌症保护的显著特征。
