Department of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Department of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
J Immunol Res. 2018 May 17;2018:8439813. doi: 10.1155/2018/8439813. eCollection 2018.
Brucellosis is one of the most prevalent zoonotic diseases in the world, but its pathogenesis is not very clear. At present, it is thought that it may be related to the immunity of T cells. The conclusions of related studies are inconsistent, and its clinical significance is not explicit. We searched published articles in electronic databases up to December 2017 identified as relating to the clinical features of human brucellosis in China. Only eight studies had sufficient quality for data extraction. Meta-analysis showed a significantly decreased proportion of CD4+ T cells in human brucellosis patients compared to healthy subject individuals. The frequency of CD8+ T cells was significantly higher in human brucellosis patients than that in the healthy control group. The pooled analysis presented a significant decrease of the CD4+/CD8+ ratio in human brucellosis patients compared to healthy subjects. There is immunologic dysfunction of T lymphocyte in patients with human brucellosis, the CD4+ and CD8+ T cells might be the important factors affecting the progress of brucellosis.
布鲁氏菌病是世界上最流行的人畜共患病之一，但发病机制尚不清楚。目前认为可能与 T 细胞免疫有关。相关研究的结论并不一致，其临床意义也不明确。我们检索了截至 2017 年 12 月发表在电子数据库中的与中国人类布鲁氏菌病临床特征相关的文章。只有八项研究的质量足以进行数据提取。Meta 分析显示，与健康对照组相比，人类布鲁氏菌病患者的 CD4+T 细胞比例显著降低。人类布鲁氏菌病患者 CD8+T 细胞的频率明显高于健康对照组。合并分析显示，与健康对照组相比，人类布鲁氏菌病患者的 CD4+/CD8+比值显著降低。人类布鲁氏菌病患者存在 T 淋巴细胞免疫功能障碍，CD4+和 CD8+T 细胞可能是影响布鲁氏菌病进展的重要因素。
