Shen Ling-Yu, Liang Cui-Mei, Yang Wen-Jin, Pan Liang, Li Hua, Hu Hui
Department of Acupuncture and Moxibustion, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China.
Zhen Ci Yan Jiu. 2018 Apr 25;43(4):255-9. doi: 10.13702/j.1000-0607.170687.
To explore the therapeutic effect of acupuncture in the treatment of polycystic ovarian syndrome (PCOS) patients with abdominal obesity by regulating glucose metabolism, insulin resistance, sex hormones, etc.
Eligible PCOS volunteers were randomly divided into treatment group(=30) and control group(=28). The treatment group received acupuncture therapy three times a week combined with diet control and exercise. EA (2 Hz/100 Hz, 4-8 mA) was applied to bilateral Daimai (GB 26)and Tianshu (ST 25) for 20 min/time, and bilateral Daheng (SP 15), Shenshu (BL 23), Ciliao (BL 32), Guilai (ST 29), Zulinqi (GB 41) and Waiguan (SJ 5) were stimulated with filiform needles, with the needles retained for 20 min. Patients of the control group were asked to restrict intake of dietary calories (low fat, appropriate proteins, and high carbohydrate) and aerobic exercise (>40 min/time), 3 times/week. The treatment duration lasted 12 weeks. Before and after the treatment, serum fasting insulin (FINS), fasting blood-glucose (FBG), Testosterone (T), luteinizing hormone (LH) and follicle stimulating hormone (FSH) contents were assayed using immuno-fluorometry, the homeostasis model assessment of insulin resistance (HOMA -IR) and ratio of LH/FSH were calculated, and body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR) were measured, separately.
Comparison with their own individual pre-treatment, the levels of FINS, HOMA -IR, T, LH, LH/FSH, BMI, WC and WHR (not FBG) in both control and treatment groups were significantly decreased (<0.05, <0.01), and the levels of FINS, HOMA-IR and WC were significantly lower in the treatment group than in the control group (<0.01, <0.05). No marked differences were found between two groups in the levels of FBG, T, LH, LH/FSH, BMI and WHR (>0.05).
Acupuncture can effectively reduce FINS, HOMA-IR and WC levels in PCOS patients with abdominal obesity, down-regulating insulin resistance, which is significantly superior to simple diet control plus exercise.
探讨针刺通过调节糖代谢、胰岛素抵抗、性激素等，对多囊卵巢综合征（PCOS）腹型肥胖患者的治疗作用。
将符合条件的PCOS志愿者随机分为治疗组（n = 30）和对照组（n = 28）。治疗组每周接受3次针刺治疗，并结合饮食控制和运动。采用疏密波（2Hz/100Hz，4 - 8mA）电针双侧带脉（GB 26）和天枢（ST 25）20分钟/次，并用毫针刺激双侧大横（SP 15）、肾俞（BL 23）、次髎（BL 32）、归来（ST 29）、足临泣（GB 41）和外关（SJ 5），留针20分钟。对照组患者需限制饮食热量摄入（低脂、适量蛋白质、高碳水化合物）并进行有氧运动（>40分钟/次），每周3次。治疗持续12周。治疗前后，采用免疫荧光法检测血清空腹胰岛素（FINS）、空腹血糖（FBG）、睾酮（T）、黄体生成素（LH）和卵泡刺激素（FSH）含量，计算胰岛素抵抗稳态模型评估（HOMA-IR）和LH/FSH比值，并分别测量体重指数（BMI）、腰围（WC）和腰臀比（WHR）。
与各自治疗前相比，对照组和治疗组的FINS、HOMA-IR、T、LH、LH/FSH、BMI、WC和WHR（不包括FBG）水平均显著降低（P < 0.05，P < 0.01），且治疗组的FINS、HOMA-IR和WC水平显著低于对照组（P < 0.01，P < 0.05）。两组间FBG、T、LH、LH/FSH、BMI和WHR水平无显著差异（P > 0.05）。
针刺可有效降低PCOS腹型肥胖患者的FINS、HOMA-IR和WC水平，下调胰岛素抵抗，显著优于单纯饮食控制加运动。
