Li Hui, Wang Dan
Department of Rehabilitation, Chongqing Jiangbei Hospital of Traditional Chinese Medicine, Chongqing, People's Republic of China.
Traditional Chinese Medicine College, Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
Int J Gen Med. 2024 Oct 25;17:4917-4928. doi: 10.2147/IJGM.S484260. eCollection 2024.
Insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) are representative metabolic diseases, and no pharmacological therapeutic strategies have been developed worldwide. In recent studies, acupuncture has increasingly been used as an integrative or complementary therapy for IR and NAFLD. In this review, we summarized 18 clinical trials and 25 animal studies to reveal the function and potential molecular mechanisms of acupuncture for IR and NAFLD treatment. We found that acupuncture can be a first-line treatment strategy for IR and has a positive therapeutic effect on NAFLD. Thus, this review provides clinicians with a deeper understanding of the scientific evidence for acupuncture treatment of IR and NAFLD. Finally, we highlighted three potential limitations of existing studies on acupuncture for the treatment of IR and NAFLD, including small sample sizes and inconsistent operating techniques.
胰岛素抵抗（IR）和非酒精性脂肪性肝病（NAFLD）是典型的代谢性疾病，目前全球尚未开发出药物治疗策略。在最近的研究中，针灸越来越多地被用作IR和NAFLD的综合或补充疗法。在本综述中，我们总结了18项临床试验和25项动物研究，以揭示针灸治疗IR和NAFLD的作用及潜在分子机制。我们发现，针灸可以作为IR的一线治疗策略，对NAFLD具有积极的治疗效果。因此，本综述为临床医生提供了对针灸治疗IR和NAFLD的科学证据的更深入理解。最后，我们强调了现有针灸治疗IR和NAFLD研究的三个潜在局限性，包括样本量小和操作技术不一致。
