水中氮杂环卡宾催化的不对称安息香反应
N-Heterocyclic Carbene-Catalyzed Asymmetric Benzoin Reaction in Water.
作者信息
Yan Jun, Sun Rong, Shi Kuangxi, Li Kai, Yang Limin, Zhong Guofu
机构信息
College of Materials, Chemistry & Chemical Engineering , Hangzhou Normal University , Hangzhou 310036 , China.
出版信息
J Org Chem. 2018 Jul 20;83(14):7547-7552. doi: 10.1021/acs.joc.8b00481. Epub 2018 Jun 25.
PMID:29888917
Abstract
A chiral N-heterocyclic carbene-catalyzed benzoin condensation reaction in water has been developed, affording α-hydroxy ketones in good to high yields and high enantioselectivities. Water was proposed as a proton shuttle in the aqueous asymmetric condensation reaction.
摘要
已开发出一种在手性 N-杂环卡宾催化下于水中进行的安息香缩合反应，能以良好至高收率和高对映选择性得到α-羟基酮。水被认为是该水相不对称缩合反应中的质子穿梭体。
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