基于樟脑的六元杂环卡宾前体的合成
Synthesis of Six-Membered -Heterocyclic Carbene Precursors Based on Camphor.
作者信息
Šegina Jan, Ciber Luka, Brodnik Helena, Požgan Franc, Svete Jurij, Štefane Bogdan, Grošelj Uroš
机构信息
Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna Pot 113, 1000 Ljubljana, Slovenia.
出版信息
Molecules. 2023 Dec 6;28(24):7973. doi: 10.3390/molecules28247973.
The - and --heterocyclic carbene precursors based on camphor were prepared diastereoselectively in five synthetic steps starting from (1)-(+)-ketopinic acid. The obtained -heterocyclic carbene precursors were investigated in an asymmetric benzoin reaction. All new compounds were fully characterized, and the absolute configurations were determined via X-ray diffraction and NOESY measurements.
基于樟脑的-和--杂环卡宾前体从(1)-(+)-酮基频哪酸开始，通过五步合成以非对映选择性方式制备。所得到的-杂环卡宾前体在不对称安息香反应中进行了研究。所有新化合物都得到了充分表征，并通过X射线衍射和NOESY测量确定了绝对构型。
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