Genetics and Molecular Biology Program, Emory University, Atlanta, GA 30322, USA.
Department of Human Genetics, Emory University, Atlanta, GA, 30322, USA.
Epigenomics. 2018 Jun;10(6):845-858. doi: 10.2217/epi-2017-0174. Epub 2018 Jun 11.
Endocrine-disrupting compounds (EDCs) are a broad class of chemicals present in many residential products that can disrupt hormone signaling and cause health problems in humans. Multigenerational cohorts, like the Michigan polybrominated biphenyl registry, are ideal for studying the effects of intergenerational exposure. Registry participants report hormone-related health problems, particularly in those exposed before puberty or those in the second generation exposed through placental transfer or breastfeeding. However, more research is needed to determine how EDCs cause health problems and the mechanisms underlying intergenerational exposure. Utilizing existing data in this registry, along with genetic and epigenetic approaches, could provide insight to how EDCs cause human disease and help to determine the risk to exposed populations and future generations.
内分泌干扰化合物 (EDCs) 是一类广泛存在于许多住宅产品中的化学物质，它们可以干扰激素信号传递，并导致人类健康问题。多代队列，如密歇根州多溴联苯登记处，是研究代际暴露影响的理想选择。登记处参与者报告了与激素相关的健康问题，特别是在那些青春期前暴露或第二代通过胎盘转移或母乳喂养暴露的人。然而，需要更多的研究来确定 EDC 如何导致健康问题以及代际暴露的潜在机制。利用该登记处现有的数据以及遗传和表观遗传方法，可以深入了解 EDC 如何导致人类疾病，并有助于确定暴露人群和后代的风险。
