Emory University School of Medicine, 101 Woodruff Circle NE, Ste 2205A, Atlanta, GA, 30322, USA.
Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA, 30322, USA.
Environ Health. 2019 Aug 23;18(1):75. doi: 10.1186/s12940-019-0509-z.
Michigan residents were directly exposed to endocrine-disrupting compounds, polybrominated biphenyl (PBB) and polychlorinated biphenyl (PCB). A growing body of evidence suggests that exposure to certain endocrine-disrupting compounds may affect thyroid function, especially in people exposed as children, but there are conflicting observations. In this study, we extend previous work by examining age of exposure's effect on the relationship between PBB exposure and thyroid function in a large group of individuals exposed to PBB.
Linear regression models were used to test the association between serum measures of thyroid function (total thyroxine (T), total triiodothyronine (T), free T, free T, thyroid stimulating hormone (TSH), and free T: free T ratio) and serum PBB and PCB levels in a cross-sectional analysis of 715 participants in the Michigan PBB Registry.
Higher PBB levels were associated with many thyroid hormones measures, including higher free T (p = 0.002), lower free T (p = 0.01), and higher free T: free T ratio (p = 0.0001). Higher PCB levels were associated with higher free T (p = 0.0002), and higher free T: free T ratio (p = 0.002). Importantly, the association between PBB and thyroid hormones was dependent on age at exposure. Among people exposed before age 16 (N = 446), higher PBB exposure was associated with higher total T (p = 0.01) and free T (p = 0.0003), lower free T (p = 0.04), and higher free T: free T ratio (p = 0.0001). No significant associations were found among participants who were exposed after age 16. No significant associations were found between TSH and PBB or PCB in any of the analyses conducted.
This suggests that both PBB and PCB are associated with thyroid function, particularly among those who were exposed as children or prenatally.
密歇根州居民直接接触到内分泌干扰化合物多溴联苯 (PBB) 和多氯联苯 (PCB)。越来越多的证据表明，接触某些内分泌干扰化合物可能会影响甲状腺功能，尤其是在儿童时期暴露的人群中，但观察结果存在冲突。在这项研究中，我们通过检查暴露年龄对暴露于 PBB 的大量个体中 PBB 暴露与甲状腺功能之间关系的影响，扩展了之前的工作。
在密歇根州 PBB 登记处的 715 名参与者的横断面分析中，使用线性回归模型来测试血清甲状腺功能（总甲状腺素 (T)、总三碘甲状腺原氨酸 (T)、游离 T、游离 T、促甲状腺激素 (TSH) 和游离 T：游离 T 比）与血清 PBB 和 PCB 水平之间的关联。
较高的 PBB 水平与许多甲状腺激素指标相关，包括游离 T 升高（p=0.002）、游离 T 降低（p=0.01）和游离 T：游离 T 比升高（p=0.0001）。较高的 PCB 水平与游离 T 升高（p=0.0002）和游离 T：游离 T 比升高（p=0.002）相关。重要的是，PBB 与甲状腺激素之间的关联取决于暴露年龄。在 16 岁之前暴露的人群中（N=446），较高的 PBB 暴露与总 T 升高（p=0.01）和游离 T 升高（p=0.0003）、游离 T 降低（p=0.04）和游离 T：游离 T 比升高（p=0.0001）相关。在 16 岁以后暴露的参与者中未发现显著关联。在进行的任何分析中，TSH 与 PBB 或 PCB 之间均未发现显著关联。
这表明 PBB 和 PCB 均与甲状腺功能相关，尤其是在儿童或产前暴露的人群中。
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