1973 - 1974年牲畜饲料受多溴联苯（PBBs）污染几十年后密歇根州成年人血清中的多溴联苯（PBBs）、多氯联苯（PCBs）与甲状腺功能
Serum Polybrominated Biphenyls (PBBs) and Polychlorinated Biphenyls (PCBs) and Thyroid Function among Michigan Adults Several Decades after the 1973-1974 PBB Contamination of Livestock Feed.
作者信息
Jacobson Melanie H, Darrow Lyndsey A, Barr Dana Boyd, Howards Penelope P, Lyles Robert H, Terrell Metrecia L, Smith Alicia K, Conneely Karen N, Marder M Elizabeth, Marcus Michele
机构信息
Department of Epidemiology, Rollins School of Public Health and Laney Graduate School, Emory University , Atlanta, Georgia, USA.
Department of Environmental Health, Rollins School of Public Health, Emory University , Atlanta, Georgia, USA.
出版信息
Environ Health Perspect. 2017 Sep 26;125(9):097020. doi: 10.1289/EHP1302.
BACKGROUND
In 1973-1974, Michigan residents were exposed to polybrominated biphenyls (PBBs) through an accidental contamination of the food supply. Residents were enrolled in a registry assembled after the incident, and they and their children participated in follow-up studies to assess subsequent health outcomes.
OBJECTIVES
We evaluated associations between serum PBBs and polychlorinated biphenyls (PCBs) and markers of thyroid function among Michigan adults.
METHODS
Serum concentrations of four PBB and four PCB congeners were measured at least once in 753 adults, including 79 women who participated in a 2004-2006 study and 683 women and men with follow-up during 2012-2015. Participants completed questionnaires on health conditions (including physician-diagnosed thyroid disease), behaviors, and demographics. Thyroid hormones were measured in a subset without thyroid disease (n=551). In multivariable linear regression models, PBB and PCB congener concentrations, on both the volume (nanogram/milliliter) and lipid (nanogram/gram lipid) basis, were assessed in relation to thyroid hormones. Logistic regression models were used to estimate associations between serum PBBs and PCBs and thyroid disease.
RESULTS
Thyroid disease was common (18% overall; 25% among women). Among women, all odds ratios (ORs) for PBB-153 and thyroid disease were positive for quintiles above the reference level, but estimates were imprecise and were without a monotonic increase. For an interquartile range (IQR) increase in PBB-153 (0.43 ng/mL), the OR (any thyroid disease)=1.12; (95% CI: 0.83, 1.52) (n=105 cases); for hypothyroidism, OR=1.35 (95% CI: 0.86, 2.13) (n=49 cases). There were 21 cases of thyroid disease in men [OR=0.69 (95% CI: 0.33); 1.44 for an IQR increase (0.75 ng/mL) in serum PBB-153]. PCB congeners were statistically significantly associated with greater total and free thyroxine and total triiodothyronine among women and with total and free triiodothyronine among men in lipid-standardized models.
CONCLUSIONS
We found some evidence to support associations of PBBs and PCBs with thyroid disease and thyroid hormone levels. https://doi.org/10.1289/EHP1302.
背景
1973年至1974年期间，密歇根州居民因食品供应意外受到多溴联苯（PBBs）污染。事件发生后，居民被纳入一个登记册，他们及其子女参与了后续研究，以评估随后的健康结果。
目的
我们评估了密歇根州成年人血清中多溴联苯（PBBs）和多氯联苯（PCBs）与甲状腺功能标志物之间的关联。
方法
在753名成年人中至少测量了一次四种PBB和四种PCB同系物的血清浓度，其中包括79名参与2004 - 2006年研究的女性，以及683名在2012 - 2015年期间接受随访的女性和男性。参与者完成了关于健康状况（包括医生诊断的甲状腺疾病）、行为和人口统计学的问卷调查。在一部分无甲状腺疾病的人群（n = 551）中测量了甲状腺激素。在多变量线性回归模型中，基于体积（纳克/毫升）和脂质（纳克/克脂质）的PBB和PCB同系物浓度与甲状腺激素相关联进行评估。逻辑回归模型用于估计血清PBBs和PCBs与甲状腺疾病之间的关联。
结果
甲状腺疾病很常见（总体为18%；女性中为25%）。在女性中，PBB - 153与甲状腺疾病的所有比值比（OR）在高于参考水平的五分位数中均为阳性，但估计值不精确且无单调增加。对于PBB - 153四分位间距（IQR）增加（0.43纳克/毫升），OR（任何甲状腺疾病）= 1.12；（95%置信区间：0.83，1.52）（n = 105例）；对于甲状腺功能减退，OR = 1.35（95%置信区间：0.86，2.13）（n = 49例）。男性中有21例甲状腺疾病[OR = 0.69（95%置信区间：0.33）；血清PBB - 153四分位间距（IQR）增加（0.75纳克/毫升）时OR = 1.44]。在脂质标准化模型中，PCB同系物与女性总甲状腺素和游离甲状腺素以及总三碘甲状腺原氨酸升高有统计学显著关联，与男性总三碘甲状腺原氨酸和游离三碘甲状腺原氨酸升高有统计学显著关联。
结论
我们发现了一些证据支持PBBs和PCBs与甲状腺疾病及甲状腺激素水平之间的关联。https://doi.org/10.1289/EHP1302
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